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https://www.um.edu.mt/library/oar/handle/123456789/82529| Title: | (Aγδβ)ο-Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA |
| Authors: | Henthorn, P. S. Smithies, O. Nakatsuji, T. Felice, Alex Gardiner, M. B. Reese, A. L. Huisman, Titus Hendrik Jan |
| Keywords: | Hemoglobin Hemoglobinopathy Thalassemia Molecular microbiology |
| Issue Date: | 1985 |
| Publisher: | Wiley-Blackwell Publishing Ltd. |
| Citation: | Henthorn, P. S., Smithies, O., Nakatsuji, T., Felice, A., Gardiner, M. B., Reese, A. L., & Huisman, T. H. J. (1985). (Aγδβ)ο-Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA. British Journal of Haematology, 59 (2), 343-356. |
| Abstract: | DNA from members of 10 Black families with conditions considered to be Gγ(δβ)ο-thalassaemia or Gγ(δβ)ο-HPFH were studied by using restriction enzyme analysis. One or more affected members from each family were shown to have the same deletion of 34 kbp of DNA in the human β-globin gene cluster. A clone spanning the deletion was isolated from the DNA of one such person and studied in detail. The deletion removed part of the Aγ and all of the Ψβ,δ and β-globin genes and is different from the four previously identified deletions which caused a condition presently known as (Aγδβ)ο-thalassaemia. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/82529 |
| Appears in Collections: | Scholarly Works - FacM&SSur |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| (Aγδβ)ο-Thalassaemia_in_Blacks_is_due_to_a_deletion_of_34_kbp_of_DNA_1985.pdf | 10.02 MB | Adobe PDF | View/Open |
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