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DC Field | Value | Language |
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dc.contributor.author | Johnson, Alex D. | - |
dc.contributor.author | Buhagiar, Joseph A. | - |
dc.contributor.author | Magri, David C. | - |
dc.date.accessioned | 2021-12-21T07:34:23Z | - |
dc.date.available | 2021-12-21T07:34:23Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Johnson, A. D., Buhagiar, J. A., & Magri, D. C. (2021). 4-Amino-1, 8-naphthalimide–ferrocene conjugates as potential multi-targeted anticancer and fluorescent cellular imaging agents. RSC Medicinal Chemistry. 12, 2060-2064. DOI: 10.1039/d1md00246e. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/85883 | - |
dc.description.abstract | Herein we present eight ferrocenyl 4-amino-1,8-naphthalimides. Designed as fluorescent logic gates for acidity and oxidisability, the molecules have been repurposed as anti-proliferation and cellular imaging agents. The compounds were studied in vitro against MCF-7 and K562 cancer cell lines by the MTT method. Compounds with protonable secondary amines tended to exhibit greater cytotoxicity than those with tertiary amines. Compounds with no measurable GI50 values within a 24 hour time window, as well as at shorter exposure times, may be suitable as fluorescent cellular imaging probes. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | The Royal Society of Chemistry | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Chemistry -- Research | en_GB |
dc.subject | Fluorescence | en_GB |
dc.subject | Charge transfer | en_GB |
dc.subject | Acidity function | en_GB |
dc.subject | Photochemotherapy | en_GB |
dc.title | 4-Amino-1,8-naphthalimide–ferrocene conjugates as potential multi-targeted anticancer and fluorescent cellular imaging agents | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1039/d1md00246e | - |
dc.publication.title | RSC Medicinal Chemistry | en_GB |
Appears in Collections: | Scholarly Works - FacSciBio Scholarly Works - FacSciChe |
Files in This Item:
File | Description | Size | Format | |
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2021 RSC Med Chem.pdf Restricted Access | 881.44 kB | Adobe PDF | View/Open Request a copy |
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