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DC Field | Value | Language |
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dc.contributor.author | Casarrubea, Maurizio | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.contributor.author | Crescimanno, Giuseppe | - |
dc.date.accessioned | 2022-01-05T07:01:29Z | - |
dc.date.available | 2022-01-05T07:01:29Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Casarrubea, M., Di Giovanni, G., & Crescimanno, G. (2021). Effects of different anxiety levels on the behavioral patternings investigated through T-pattern analysis in Wistar rats tested in the hole-board apparatus. Brain Sciences, 11(6), 714. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/86376 | - |
dc.description.abstract | The Hole-Board is an ethologically based tool for investigating the anxiety-related behavior of rats following manipulation of the central anxiety level. The present paper aims to assess behavioral patterning following pharmacological manipulation of emotional assets in Wistar rats tested in this experimental apparatus. For this purpose, the behavior of three groups of rats injected with saline, diazepam or FG7142 was evaluated using conventional quantitative and multivariate Tpattern analyses. The results demonstrate that quantitative analyses of individual components of the behavior, disjointed from the comprehensive behavioral structure, are of narrow utility in the understanding of the subject’s emotional condition. Among the components of the behavioral repertoire in rodents tested in the Hole-Board, Edge-Sniff and Head-Dip represent the most significant ones to rate anxiety level. They are characterized by a strong bivariate relationship and are also firmly part of the behavioral architecture, as revealed by the T-pattern analysis (TPA), a multivariate technique able to detect significant relationships among behavioral events over time. Edge-Sniff ! Head-Dip sequences, in particular, are greatly influenced by the level of anxiety: barely detectable in control animals, they completely disappear in subjects with a reduced level of anxiety and are present in almost 25% of the total of T-patterns detected in subjects whose anxiety level increased. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | MDPI | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Anxiety disorders -- Physiological aspects | en_GB |
dc.subject | Animal models in research | en_GB |
dc.subject | Behavioral assessment | en_GB |
dc.subject | Diazepam | en_GB |
dc.subject | Tranquilizing drugs | en_GB |
dc.title | Effects of different anxiety levels on the behavioral patternings investigated through T-pattern analysis in Wistar rats tested in the hole-board apparatus | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3390/brainsci11060714 | - |
dc.publication.title | Brain Sciences | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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File | Description | Size | Format | |
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Effects_of_different_anxiety_levels_on_the_behavioral_patternings_investigated_through_T_pattern_analysis_ 2021.pdf | 2.91 MB | Adobe PDF | View/Open |
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