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DC Field | Value | Language |
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dc.contributor.author | Reddavide, Rosa | - |
dc.contributor.author | Cisternino, Anna Maria | - |
dc.contributor.author | Inguaggiato, Rosa | - |
dc.contributor.author | Rotolo, Ornella | - |
dc.contributor.author | Zinzi, Iris | - |
dc.contributor.author | Veronese, Nicola | - |
dc.contributor.author | Guerra, Vito | - |
dc.contributor.author | Fucilli, Fabio | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.contributor.author | Leandro, Gioacchino | - |
dc.contributor.author | Giannico, Sara | - |
dc.contributor.author | Caruso, Maria Gabriella | - |
dc.date.accessioned | 2022-01-11T13:44:38Z | - |
dc.date.available | 2022-01-11T13:44:38Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Reddavide, R., Cisternino, A. M., Inguaggiato, R., Rotolo, O., Zinzi, I., Veronese, N.,...Caruso, M. G. (2019). Non-alcoholic fatty liver disease is associated with higher metabolic expenditure in overweight and obese subjects: a case-control study. Nutrients, 11(8), 1830. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/86720 | - |
dc.description.abstract | Non-alcoholic fatty liver disease (NAFLD) is a common condition in Western countries. However, their metabolic characteristics are poorly known even though they could be important. Therefore, the objective of this study was to measure resting metabolic parameters in overweight/obese adults with hepatic steatosis compared to controls, matched for age, sex, and obesity level. Hepatic steatosis was diagnosed with liver ultrasound. Energy metabolism was measured with indirect calorimetry: energy expenditure (REE), predicted REE, the ratio between REE and the predicted REE, and the respiratory quotient (RQ) were reported. We measured some anthropometric, body composition, and bio-humoral parameters; 301 participants with NAFLD were matched for age, sex, and obesity level with 301 participants without NAFLD. People with NAFLD showed significantly higher REE (1523 ± 238 vs. 1464 ± 212 kcal, p = 0.005), REE/REE predicted ratio (98.2 ± 9.4 vs. 95.7 ± 8.1, p = 0.002), and RQ (0.88 ± 0.08 vs. 0.85 ± 0.07, p = 0.03). Moreover, the NAFLD group had significantly higher inflammatory and insulin-resistance parameters compared to controls. In conclusion, NAFLD is associated with a significantly higher metabolic expenditure, as measured with indirect calorimetry, compared to a similar cohort of individuals without this condition. Higher inflammatory levels in patients with NAFLD can probably explain our findings, even if other research is needed on this issue. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | MDPI | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Non-alcoholic fatty liver disease -- Case studies | en_GB |
dc.subject | Liver -- Diseases -- Case studies | en_GB |
dc.subject | Obesity -- Complications -- Case studies | en_GB |
dc.subject | Energy metabolism | en_GB |
dc.subject | Overweight persons -- Case studies | en_GB |
dc.title | Non-alcoholic fatty liver disease is associated with higher metabolic expenditure in overweight and obese subjects : a case-control study | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3390/nu11081830 | - |
dc.publication.title | Nutrients | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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Non_alcoholic_fatty_liver_disease_is_associated_with_higher_metabolic_expenditure_in_overweight_and_obese_subjects_2019.pdf | 255.22 kB | Adobe PDF | View/Open |
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