Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/87266
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Riva, Nicoletta | - |
dc.contributor.author | Hickey, Kieron | - |
dc.contributor.author | Bertù, Lorenza | - |
dc.contributor.author | Zammit, Daniel | - |
dc.contributor.author | Spiteri, Silvana | - |
dc.contributor.author | Kitchen, Steve | - |
dc.contributor.author | Makris, Michael | - |
dc.contributor.author | Ageno, Walter | - |
dc.contributor.author | Gatt, Alexander | - |
dc.date.accessioned | 2022-01-19T12:30:08Z | - |
dc.date.available | 2022-01-19T12:30:08Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Riva, N., Vella, K., Hickey, K., Bertù, L., Zammit, D., Spiteri, S., ... & Gatt, A. (2018). Biomarkers for the diagnosis of venous thromboembolism: D-dimer, thrombin generation, procoagulant phospholipid and soluble P-selectin. Journal of Clinical Pathology, 71(11), 1015-1022. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/87266 | - |
dc.description.abstract | Background: The diagnostic algorithm for venous thromboembolism (VTE) currently involves a composite of pre-test probability, D-dimer and imaging. Other laboratory tests, however, may assist in the identification of patients with VTE. Aim: To assess the accuracy of different coagulation tests (D-dimer, thrombin generation, phospholipid-dependent (PPL) clotting time, soluble P-selectin (sP-selectin)) as biomarkers of acute VTE. Methods: Random samples arriving at the Coagulation Laboratory at Mater Dei Hospital (Msida, Malta) from the Accident and Emergency Department with a request for D-dimer measurement were collected between August 2015 and February 2016. The following tests were performed: Innovance D-dimer (Siemens Healthcare Diagnostics), HemosIL D-dimer HS (Instrumentation Laboratory), thrombin generation (using the calibrated automated thrombogram), STA Procoag PPL (Diagnostica Stago) and sP-selectin (Affymetrix; eBioscience). VTE was objectively confirmed by compression ultrasonography, CT pulmonary angiography or ventilation/perfusion lung scan. Results: 100 samples were collected (33 with VTE). A strong positive linear correlation was found between the two D-dimer tests (r=0.97, p<0.001). Patients with VTE showed significantly higher sP-selectin concentrations compared with patients without VTE (75.7 ng/mL vs 53.0 ng/mL, p<0.001). In the random forest plot, the two D-dimer assays showed the highest variable importance, followed by sP-selectin. A sP-selectin cut-off of 74.8 ng/mL was associated with 72.7% sensitivity and 78.2% specificity for acute VTE in our cohort. Conclusion: Our results confirmed D-dimer as the main biomarker of VTE and speculated a role for sP-selectin. The impact of thrombin generation was limited and no role emerged for the PPL clotting time. These observations need to be confirmed in large management studies. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | BMJ | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Biochemical markers | en_GB |
dc.subject | Thromboembolism | en_GB |
dc.title | Biomarkers for the diagnosis of venous thromboembolism : D-dimer, thrombin generation, procoagulant phospholipid and soluble P-selectin | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1136/ jclinpath-2018-205293 | - |
dc.publication.title | Journal of Clinical Pathology | en_GB |
dc.contributor.author2 | Vella, Kevin | - |
Appears in Collections: | Scholarly Works - FacEngEE Scholarly Works - FacM&SPat |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Riva et al (JCP 2018).pdf Restricted Access | 1.43 MB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.