Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/87371
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gulcebi, Medine I. | - |
dc.contributor.author | Bartolini, Emanuele | - |
dc.contributor.author | Lee, Omay | - |
dc.contributor.author | Lisgaras, Christos Panagiotis | - |
dc.contributor.author | Onat, Filiz | - |
dc.contributor.author | Mifsud, Janet | - |
dc.contributor.author | Striano, Pasquale | - |
dc.contributor.author | Vezzani, Annamaria | - |
dc.contributor.author | Hildebrand, Michael S. | - |
dc.contributor.author | Jimenez-Jimenez, Diego | - |
dc.contributor.author | Junck, Larry | - |
dc.contributor.author | Lewis-Smith, David | - |
dc.contributor.author | Scheffer, Ingrid E. | - |
dc.contributor.author | Thijs, Roland D. | - |
dc.contributor.author | Zuberi, Sameer M. | - |
dc.contributor.author | Blenkinsop, Stephen | - |
dc.contributor.author | Fowler, Hayley J. | - |
dc.contributor.author | Foley, Aideen | - |
dc.date.accessioned | 2022-01-20T11:31:49Z | - |
dc.date.available | 2022-01-20T11:31:49Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.citation | Gulcebi, M., Bartolini, E., Lee, O., Lisgaras, C., Onat, F., Mifsud, J., ... Sisodiya, S. (2021). Climate change and epilepsy : insights from clinical and basic science studies. Epilepsy & Behavior, 116, 107791. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/87371 | - |
dc.description.abstract | Climate change is with us. As professionals who place value on evidence-based practice, climate change is something we cannot ignore. The current pandemic of the novel coronavirus, SARS-CoV-2, has demonstrated how global crises can arise suddenly and have a significant impact on public health. Global warming, a chronic process punctuated by acute episodes of extreme weather events, is an insidious global health crisis needing at least as much attention. Many neurological diseases are complex chronic conditions influenced at many levels by changes in the environment. This review aimed to collate and evaluate reports from clinical and basic science about the relationship between climate change and epilepsy. The keywords climate change, seasonal variation, temperature, humidity, thermoregulation, biorhythm, gene, circadian rhythm, heat, and weather were used to search the published evidence. A number of climatic variables are associated with increased seizure frequency in people with epilepsy. Climate change-induced increase in seizure precipitants such as fevers, stress, and sleep deprivation (e.g. as a result of more frequent extreme weather events) or vector-borne infections may trigger or exacerbate seizures, lead to deterioration of seizure control, and affect neurological, cerebrovascular, or cardiovascular comorbidities and risk of sudden unexpected death in epilepsy. Risks are likely to be modified by many factors, ranging from individual genetic variation and temperature-dependent channel function, to housing quality and global supply chains. According to the results of the limited number of experimental studies with animal models of seizures or epilepsy, different seizure types appear to have distinct susceptibility to seasonal influences. Increased body temperature, whether in the context of fever or not, has a critical role in seizure threshold and seizure-related brain damage. Links between climate change and epilepsy are likely to be multifactorial, complex, and often indirect, which makes predictions difficult. We need more data on possible climate-driven altered risks for seizures, epilepsy, and epileptogenesis, to identify underlying mechanisms at systems, cellular, and molecular levels for better understanding of the impact of climate change on epilepsy. Further focussed data would help us to develop evidence for mitigation methods to do more to protect people with epilepsy from the effects of climate change. | en_GB |
dc.description.sponsorship | We are grateful to the Epilepsy Society for their support of this work, and funding to SMS. This work was partly carried out at NIHR University College London Hospitals Biomedical Research Centre, which receives a proportion of funding from the UK Department of Health’s NIHR Biomedical Research Centres funding scheme. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Climatic changes -- Health aspects | en_GB |
dc.subject | Global warming | en_GB |
dc.subject | Public health | en_GB |
dc.subject | Epilepsy -- Etiology | en_GB |
dc.title | Climate change and epilepsy : insights from clinical and basic science studies | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | j.yebeh.2021.107791 | - |
dc.publication.title | Epilepsy & Behavior | en_GB |
Appears in Collections: | Scholarly Works - FacM&SCPT |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S1525505021000251-main.pdf Restricted Access | 478.67 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.