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DC Field | Value | Language |
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dc.contributor.author | Mifsud, Janet | - |
dc.contributor.author | Soler, D. | - |
dc.contributor.author | Shabbi, H. | - |
dc.date.accessioned | 2022-01-28T12:54:18Z | - |
dc.date.available | 2022-01-28T12:54:18Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Mifsud, J., Soler, D., & Shabbi, H. (2010). P10-drugs for half the world : paediatric clinical pharmacology using Adapt® in paediatric patients : pharmacokinetic modelling for Lamotrigine. Basic & Clinical Pharmacology & Toxicology, 107(s1), 455-456. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/87854 | - |
dc.description.abstract | It is estimated that around 70 % of medicinal products used in paediatric population have never been specifically evaluated for use in that age group. There is still a lack of models that will allow accurate predictions of drug levels in these populations. This is of particular importance in a chronic neurological condition such as epilepsy. In this study, a sparse data model, using AdaptÒ software was developed for lamotrigine in a group of paediatric patients. Plasma lamotrigine levels in 20 paediatric patients (mean ± S.D., age 8.85 ± 3.47 years and weight, 32.22 ±20.81 kg) were measured. The pharmacokinetic parameters in the four groups (lamotrigine alone, with valproate, with carbamazepine, and with clonazepam) were estimated. The only significant difference (P < 0.05)was obtained between the four groups in the case of estimated volume of distribution, predicated minimum plasma concentration, and area under the curve. [excerpt] | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | John Wiley & Sons, Inc. | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Pharmacokinetics -- Mathematical models | en_GB |
dc.subject | Pharmacokinetics -- Data processing | en_GB |
dc.subject | Clinical pharmacology | en_GB |
dc.subject | Pediatric pharmacology | en_GB |
dc.title | P10-drugs for half the world : paediatric clinical pharmacology using Adapt® in paediatric patients : pharmacokinetic modelling for Lamotrigine | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.bibliographicCitation.conferencename | 16th World Congress of Basic and Clinical Pharmacology | en_GB |
dc.bibliographicCitation.conferenceplace | Copenhagen, Denmark, 17-23/07/2010 | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.publication.title | Basic & Clinical Pharmacology & Toxicology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SCPT |
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File | Description | Size | Format | |
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P10-Drugs For Half The World Paediatric Clinical Pharmacology Using Adapt®.pdf Restricted Access | 82.57 kB | Adobe PDF | View/Open Request a copy |
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