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https://www.um.edu.mt/library/oar/handle/123456789/88435| Title: | Effect of antiepileptic drugs on in-vitro lymphocyte proliferation assays |
| Authors: | Mifsud, Janet Gafa, M. Micallef, M. Debono, A. G. Ellul-Micallef, Roger |
| Keywords: | Anticonvulsants -- Side effects Drug interactions T cells B cells Lymphocytes -- Metabolism |
| Issue Date: | 2004-06 |
| Publisher: | John Wiley & Sons, Inc. |
| Citation: | Mifsud, J., Gafa, M., Micallef, M., Debono, A. G., & Ellul-Micallef, R. (2004). Effect of antiepileptic drugs on in-vitro lymphocyte proliferation assays. Epilepsia, 45(s3), 127. |
| Abstract: | PURPOSE: Epilepsy is a common neurological condition with an estimated incidence of about 1% of the total population. Studies have shown that many traditional antiepileptic drugs (AEDs) alter immunoglobulin (Ig) levels in patients on this therapy. The objective of this study was to investigate the Ig depressing effect of traditional AEDs and newer AEDs using in-vitro lymphocyte proliferation assays. METHOD: We inhibited lymphocyte proliferation in incubated cell cultures using varying concentrations (100mg/ml to1 00 pg/ml) of vigabatrin (VGB), gabapentin (GBP), and phenobarbitone (PBT). The assay was based on a method that uses isotope labelled nucleotide Tritium thymidine [3H] incorporated into new DNA on cell cultures obtained from donor blood samples. [excerpt] |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/88435 |
| Appears in Collections: | Scholarly Works - FacM&SCPT |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Effect of antiepileptic drugs on in-vitro lymphocyte proliferation assays.pdf Restricted Access | 128.39 kB | Adobe PDF | View/Open Request a copy |
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