Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/88491
Title: | Modelling pharmacokinetics for antiepileptic drugs in paediatrics |
Authors: | Mifsud, Janet Shabbi, H. Soler, D. |
Keywords: | Pharmacokinetics -- Mathematical models Pharmacokinetics -- Data processing Anticonvulsants -- Mechanism of action Epilepsy in children |
Issue Date: | 2006-09 |
Publisher: | John Wiley & Sons, Inc. |
Citation: | Mifsud, J., Shabbi, H., & Soler, D. (2006). Modelling pharmacokinetics for antiepileptic drugs in paediatrics. European Journal of Neurology, 13(s2), 122-123. |
Abstract: | AIMS: Most physicians use ad hoc reasoning in the design of dosage regimens for antiepileptic drugs in children as there is still a lack of satisfactory models and software packages that will allow accurate predictions of drug levels. METHODS: In this study, the value of a sparse data model, using AdaptĀ® software was developed for lamotrigine in paediatric patients. Plasma lamotrigine levels in 20 paediatric patients were measured. The pharmacokinetic parameters in the four groups(lamotrigine alone, valproate co-medication group, carbamazepine co-medication group, and clonazepam co-medication group) were estimated in this study using model independent pharmacokinetic equations. [excerpt] |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/88491 |
Appears in Collections: | Scholarly Works - FacM&SCPT |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Modelling pharmacokinetics for antiepileptic drugs in paediatrics.pdf Restricted Access | 51.84 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.