Therapeutic drug monitoring of lamotrigine in a paediatric population

Mifsud, Janet; Shabbi, H.; Soler, D.

Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/88492

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DC Field	Value	Language
dc.contributor.author	Mifsud, Janet	-
dc.contributor.author	Shabbi, H.	-
dc.contributor.author	Soler, D.	-
dc.date.accessioned	2022-02-08T07:35:55Z	-
dc.date.available	2022-02-08T07:35:55Z	-
dc.date.issued	2006-12	-
dc.identifier.citation	Mifsud, J., Shabbi, H., & Soler, D. (2006). Therapeutic drug monitoring of lamotrigine in a paediatric population. Epilepsia, 47(s3), 124-125.	en_GB
dc.identifier.uri	https://www.um.edu.mt/library/oar/handle/123456789/88492	-
dc.description.abstract	PURPOSE: Therapeutic drug monitoring is important for drugs that exhibit interindividual variability in pharmacokinetics, and where drug-drug interactions, concurrent disease or age alters the kinetics of that drug. This is of particular importance in a chronic neurological condition such as epilepsy. In this study, the value of therapeutic drug monitoring for lamotrigine, a novel antiepileptic drug, was investigated in a group of paediatric patients.	en_GB
dc.description.abstract	METHOD: Plasma lamotrigine levels in 20 paediatric patients (mean ±S.D., age 8.85±3.47 years and weight, 32.22±20.81 kg) were measured using a novel validated high performance liquid chromatography (HPLC) technique that gave a retention time for lamotrigine and internal standard of 1.258 min and 2.30 min respectively. The method proved to be linear, precise and reproducible over the plasma concentration range of 0.08–20mg/.	en_GB
dc.description.abstract	[excerpt]	en_GB
dc.language.iso	en	en_GB
dc.publisher	John Wiley & Sons, Inc.	en_GB
dc.rights	info:eu-repo/semantics/restrictedAccess	en_GB
dc.subject	Drug monitoring	en_GB
dc.subject	Drug interactions	en_GB
dc.subject	Lamotrigine	en_GB
dc.subject	Epilepsy in children	en_GB
dc.subject	Anticonvulsants	en_GB
dc.title	Therapeutic drug monitoring of lamotrigine in a paediatric population	en_GB
dc.type	article	en_GB
dc.rights.holder	The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.	en_GB
dc.bibliographicCitation.conferencename	7th European Congress on Epileptology	en_GB
dc.bibliographicCitation.conferenceplace	Helsinki, Finland, 2-6/07/2006	en_GB
dc.description.reviewed	peer-reviewed	en_GB
dc.publication.title	Epilepsia	en_GB
Appears in Collections:	Scholarly Works - FacM&SCPT

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