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DC Field | Value | Language |
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dc.contributor.author | Gruppetta, Mark | - |
dc.contributor.author | Vassallo, Josanne | - |
dc.date.accessioned | 2022-02-17T08:17:00Z | - |
dc.date.available | 2022-02-17T08:17:00Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | Gruppetta, M., & Vassallo, J. (2016). Outcomes of surgically treated nonfunctioning pituitary adenomas. Endocrine Abstracts, 41, EP881. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/89298 | - |
dc.description.abstract | INTRODUCTION: The sequelae of surgically treated non-functioning pituitary adenomas (NFPA) is an important area of study to help plan management. The aim was to study all Maltese patients who had a surgically treated NFPA and analyse the results of surgery, risk factors for tumour recurrence/regrowth and the role of postoperative radiotherapy. | en_GB |
dc.description.abstract | MATERIALS AND METHODS: One hundred and seventy-five patients were identified as having a NFPA of whom 77 had underwent pituitary surgery. Detailed analysis of these patients was done including their demographic details, surgical details, post-surgical management, regrowth and recurrence patterns. | en_GB |
dc.description.abstract | RESULTS: 63.6% of patients presented with visual field defects, 40.3% had headaches at presentation and 87.0% had chiasmal compression by their NFPA. Residual tumour postoperatively was evident in 67.5% of patients while 29.9% of patients had immediate postoperative radiotherapy. Recurrence /regrowth was documented in 18.2% of patients within a median time of 3.2 (IQR: 1.6–5.6) years. Factors that were found to be statistically significantly associated with a higher rate of regrowth using Kaplan-Meier estimates were the presence of residual tumour (P=0.036), presence of cavernous sinus invasion (P=0.034) and the lack of postoperative radiotherapy (P=0.004). Independent risk factors for tumour regrowth using multivariate Cox hazard analysis were absence of post-op radiotherapy (P=0.010) and cavernous sinus invasion (P=0.020). | en_GB |
dc.description.abstract | CONCLUSION: By studying this cohort of patients we were able to characterise better the outcomes of NFPA management and outline risk factors which can effect prognosis. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Bioscientifica | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Pituitary neoplasms | en_GB |
dc.subject | Pituitary gland -- Tumors -- Surgery | en_GB |
dc.subject | Postoperative care -- Malta | en_GB |
dc.title | Outcomes of surgically treated nonfunctioning pituitary adenomas | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.bibliographicCitation.conferencename | 18th European Congress of Endocrinology | en_GB |
dc.bibliographicCitation.conferenceplace | Munich, Germany, 28-31/05/2016 | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1530/endoabs.41.EP881 | - |
dc.publication.title | Endocrine Abstracts | en_GB |
Appears in Collections: | Scholarly Works - FacM&SMed |
Files in This Item:
File | Description | Size | Format | |
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Outcomes of surgically treated nonfunctioning pituitary adenomas.pdf | 1.82 MB | Adobe PDF | View/Open |
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