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DC Field | Value | Language |
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dc.contributor.author | Deidda, Gabriele | - |
dc.contributor.author | Crunelli, Vincenzo | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.date.accessioned | 2022-03-02T15:12:14Z | - |
dc.date.available | 2022-03-02T15:12:14Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Deidda, G., Crunelli, V., & Di Giovanni, G. (2021). 5-HT/GABA interaction in epilepsy. Progress in Brain Research, 259, 265-286. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/90194 | - |
dc.description.abstract | Epilepsy is a neurological condition characterized by synchronous neuronal oscillations (seizures) in the electroencephalogram. Seizures are classified in focal or generalized (depending on the brain territory interested during seizures), and in convulsive and/or not convulsive (depending on the presence or not of involuntary movements). The current pharmacological treatments are mainly based on GABA modulation although different neurotransmitters are also involved in epilepsy, including serotonin. However despite much extensive progress in the understanding of epilepsy mechanisms, still, a percentage of people with epilepsy are pharmaco-resistant calling for the need for new therapeutic targets. Here we review preclinical and human evidence showing that serotonin modulates epilepsy that this likely happens via a major modulation/interaction with GABA. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Epilepsy | en_GB |
dc.subject | Serotonin -- Mechanism of action | en_GB |
dc.subject | Gamma-aminobutyric acid | en_GB |
dc.subject | Convulsions | en_GB |
dc.title | 5-HT/GABA interaction in epilepsy | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/bs.pbr.2021.01.008 | - |
dc.publication.title | Progress in Brain Research | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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