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Title: | Novel interactors of the Drosophila Survival Motor Neuron (SMN) Complex suggest its full conservation |
Authors: | Lanfranco, Maia Cacciottolo, Rebecca Borg, Rebecca M. Vassallo, Neville Juge, François Bordonné, Rémy Cauchi, Ruben J. |
Keywords: | Sabbat Drosophila Amyotrophic lateral sclerosis Motor neurons |
Issue Date: | 2017 |
Publisher: | Federation of European Biochemical Societies |
Citation: | Lanfranco, M., Cacciottolo, R., Borg, R.M., Vassallo, N., Juge, F., Bordonné, R., & Cauchi, R.J. (2017). Novel interactors of the Drosophila Survival Motor Neuron (SMN) Complex suggest its full conservation. FEBS Letters, 591, 3600-3614. |
Abstract: | The Spinal Muscular Atrophy disease protein Survival Motor Neuron (SMN) operates as part of a multiprotein complex whose components also include Gemins 2-8 and Unrip. The fruit fly Drosophila melanogaster is thought to have a slightly smaller SMN complex comprised of SMN, Gemin2/3/5 and, possibly, Unrip. Based upon in vivo interaction methods, we have identified novel interacting partners of the Drosophila SMN complex with homologies to Gemin4/6/7/8. The Gemin4 and Gemin8 orthologues are required for neuromuscular function and survival. The Gemin6/7/Unrip module can be recruited via the SMN-associated Gemin8, hence mirroring the human SMN complex architecture. Our findings lead us to propose that an elaborate SMN complex that is typical in metazoans is also present in Drosophila. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/90341 |
Appears in Collections: | Scholarly Works - FacM&SPB |
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