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DC Field | Value | Language |
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dc.contributor.author | Galati, Salvatore | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.date.accessioned | 2022-03-07T06:38:57Z | - |
dc.date.available | 2022-03-07T06:38:57Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Galati, S., & Di Giovanni, G. (2013). Intracerebral human microdialysis in Parkinson’s disease. In: G. Di Giovanni, V. Di Matteo (eds.), Microdialysis Techniques in Neuroscience (pp. 209-223). Totowa: Humana Press. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/90535 | - |
dc.description.abstract | Microdialysis (MD) procedure is a versatile technique that allows the analysis of small molecular weight compounds from the interstitial space in different tissues. MD was used extensively in neuroscience animal studies at the end of last century, while only a single MD study in the human brain was performed at the end of 1980s. In contrast, over the last decade MD has been applied in humans mainly in neurological disorders, such as stroke, epilepsy, and Parkinson’s disease (PD). In these disorders MD has allowed quantification of neurotransmitters, peptides, and hormones giving precious information in research as well as in clinical practice. Microdialysis in awake PD patients in conjunction with deep brain stimulation (DBS) surgery has received increasing interest, but is nonetheless still a novel approach. It is likely that MD will be instrumental as a research tool in clarifying important open issues relating to the basal ganglia functions and dysfunctions. The present chapter will summarize the principles of MD and its involvement in research studies in PD in humans, illuminating the limits and the future applications of this procedure. | en_GB |
dc.description.sponsorship | Authors are indebted to the EU COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” for supporting our international collaboration. The research at the Ospedale Civico (GS) was supported by the Fondazione per lo Studio delle Malattie Neurodegenerative delle Persone Adulte e dell’Anziano, Lugano, Switzerland. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Humana Press | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Brain microdialysis | en_GB |
dc.subject | Deep brain stimulation | en_GB |
dc.subject | Parkinson's disease | en_GB |
dc.subject | Subthalamic nucleus | en_GB |
dc.subject | Substantia nigra | en_GB |
dc.subject | Basal ganglia | en_GB |
dc.title | Intracerebral human microdialysis in Parkinson’s disease | en_GB |
dc.title.alternative | Microdialysis techniques in neuroscience | en_GB |
dc.type | bookPart | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1007/978-1-62703-173-8_10 | - |
Appears in Collections: | Scholarly Works - FacM&SPB |
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Intracerebral Human Microdialysis in Parkinson’s Disease.pdf Restricted Access | 386.65 kB | Adobe PDF | View/Open Request a copy |
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