1. OAR@UM
  2. Faculty of Medicine and Surgery
  3. Department of Physiology and Biochemistry
  4. Scholarly Works - FacM&SPB
Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/90573
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCrunelli, Vincenzo-
dc.contributor.authorVenzi, Marcello-
dc.contributor.authorDe Deurwaerdère, Philippe-
dc.contributor.authorDi Giovanni, Giuseppe-
dc.date.accessioned2022-03-07T09:42:42Z-
dc.date.available2022-03-07T09:42:42Z-
dc.date.issued2018-
dc.identifier.citationCrunelli, V., Venzi, M., Deurwaerdère, P. D., & Giovanni, G. D. (2018). Role of Serotonin2A (5-HT 2A) Receptors in Epilepsy. In: B. P. Guiard, & G. Di Giovanni (eds.), 5-HT2A Receptors in the Central Nervous System (pp. 375-394). Cham: Humana Press.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/90573-
dc.description.abstract5-Hydroxytryptamine 2A receptors (5-HT2ARs), have been implicated in various psychiatric and neurological disorders, including epilepsy. Interestingly, epileptic patients commonly present comorbid psychiatric symptoms, and a bidirectional link between depression and epilepsy has been suggested. Therefore, the alteration of 5-HT2A signalling might represent a common anatomical and neurobiological substrate of both pathologies. After a brief presentation of the role of 5-HT in epilepsy, this chapter illustrates how 5-HT2A receptors may directly or indirectly control neuronal excitability in networks involved in different types of epilepsy. It also synthetizes the preclinical and clinical evidence, demonstrating the role of these receptors in antiepileptic responses.en_GB
dc.description.sponsorshipOur work in this area was supported by the ERUK (grant P1202 to VC and GDG), the Malta Council of Science and Technology (grant R&I-2013-14 to GDG and VC) and EU COST Action CM1103 (GDG and PDD).en_GB
dc.language.isoenen_GB
dc.publisherHumana Pressen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectSerotoninen_GB
dc.subjectReceptors, Serotoninen_GB
dc.subjectAntidepressantsen_GB
dc.subjectEpilepsyen_GB
dc.titleRole of Serotonin2A (5-HT2A) receptors in epilepsyen_GB
dc.title.alternative5-HT2A receptors in the central nervous systemen_GB
dc.typebookParten_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1007/978-3-319-70474-6_16-
Appears in Collections:Scholarly Works - FacM&SPB

Files in This Item:
File Description SizeFormat 
Role of Serotonin2A 5-HT2A receptors in epilepsy.pdf
  Restricted Access		307.47 kBAdobe PDFView/Open Request a copy
Show simple item record Statistics


Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.