Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/90578
Title: | Preferential modulation of the GABAergic vs. dopaminergic function in the substantia nigra by 5-HT2C receptor |
Other Titles: | The Basal Ganglia IX |
Authors: | Di Giovanni, Giuseppe Di Matteo, Vincenzo Pierucci, Massimo Esposito, Ennio |
Keywords: | Basal ganglia -- Diseases Serotonin Basal ganglia GABA Parkinson's disease |
Issue Date: | 2009 |
Publisher: | Springer |
Citation: | Giovanni, G. D., Matteo, V. D., Pierucci, M., & Esposito, E. (2009). Preferential modulation of the GABAergic vs. dopaminergic function in the substantia nigra by 5-HT 2C Receptor. In: H. J. Groenewegen, P. Voorn, H. W. Berendse, A. B. Mulder, & A. R. Cools (eds.), The Basal Ganglia IX (pp. 285-296). New York: Springer. |
Abstract: | Serotonin (5-HT) is intimately involved in the modulation of the basal ganglia circuitry and in its pathologies. The 5-HT pivotal role is supported by anatomical evidence demonstrating a large serotonergic innervation throughout the basal ganglia, with the highest concentration of this indole in the substantia nigra (SN). Among all the 5-HT receptors present in the SN, the 5-HT2C receptor subtype seems to be one of the principal receptors through which 5-HT exerts its function. In this chapter, we present in vivo electrophysiology and microdialysis evidence showing that the selective activation of 5-HT2C receptors does not affect dopaminergic function whereas it has a profound impact on GABAergic function in the substantia nigra pars reticulata (SNr). 5-HT excites the neurons of the SNr by acting on 5-HT2C receptors, and this control seems to be phasic rather than tonic in nature. Consequently, activation of 5-HT2C receptors boosts the concentration of GABA in the SNr, likely increasing GABA somatodendritic release from SNr neurons and from other GABA-containing neurons projecting to the SNr as well. Therefore, drugs acting on 5-HT2C receptors may provide a novel non-dopaminergic target for improving therapies for some basal ganglia disorders such as Parkinson’s disease. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/90578 |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Preferential Modulation of the GABAergic.pdf Restricted Access | 654.14 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.