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dc.contributor.authorBenigno, Arcangelo-
dc.contributor.authorDi Matteo, Vincenzo-
dc.contributor.authorPierucci, Massimo-
dc.contributor.authorCrescimanno, Giuseppe-
dc.contributor.authorEsposito, Ennio-
dc.contributor.authorLicciardi, A.-
dc.contributor.authorDi Giovanni, Giuseppe-
dc.date.accessioned2022-03-16T06:07:06Z-
dc.date.available2022-03-16T06:07:06Z-
dc.date.issued2007-
dc.identifier.citationBenigno, A., Di Matteo, V., Pierucci, M., Crescimanno, G., Esposito, E., Licciardi, A., & Di Giovanni, G. (2007). Involvement of nitric oxide in the nigrostriatal dopaminergic system degeneration : a study on the 6-OHDA model of Parkinson's disease. 58° Congresso della Società Italiana di Fisiologia, Lecce.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/91467-
dc.description.abstractAIM: The present study was undertaken to explore the involvement of nitric oxide (NO) in the 6-hydroxydopamine (6-OHDA) experimental model of Parkinson's disease in rats. The effect of pharmacological manipulation of NO system was evaluated on striatal dopamine (DA) levels decrease produced by the toxin compare with the right levels.en_GB
dc.description.abstractMETHODS: Experiments were carried out on Sprague- Dawley rats. In the control-lesioned group (n = 7), 6-OHDA (5µg) was infused in the left substantia nigra pars compacta (SNc). A second lesioned group (n = 7), 50 mg/kg i.p. of the NO synthase (NOS) inhibitor, 7-nitroindazole (7- NI), was administrated 1 h before the toxin infusion. A third lesioned group, 40 mg/kg i.p. of molsidomine (MOL), a NO donor, was injected 1 h before the toxin. In a fourth group (n = 7), 7-NI and MOL were coinjected 1 h before the toxin. Four sham groups (n = 7, each) received similar pharmacological treatment, nil, 7-NI, MOL, 7-NI+MOL. After a week from the lesion, rats were sacrificed and their brains removed and the striatum of both sides was collected. The samples were analyzed by reversed-phase HPLC with electrochemical detection.en_GB
dc.description.abstractRESULTS: The levels of DA in the left striata were -90.6 ± 9.5% in the control-lesioned animals, -35.3 ± 4.4% in the 7-NI group, -91.5 ± 6.4% in the MOL group and -88 ± 5.1% in the 7-NI+MOL group. In the shame groups 7-NI and MOL did not affected DA striatal levels.en_GB
dc.description.abstractCONCLUSION: 7-NI significantly restored the striatal DA levels in 6- OHDA treated rats. The protective effect was lost when NO levels were augmented by co-treatment with MOL. Thus a possible role of NO in 6- OHDA induced neurodegeneration is suggested as well of a protective benefit for inhibitors of NOS in the treatment of Parkinson disease.en_GB
dc.language.isoenen_GB
dc.publisherSocietà Italiana di Fisiologiaen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectNitric oxideen_GB
dc.subjectDopaminergic mechanismsen_GB
dc.subjectOxidopamineen_GB
dc.subjectParkinson's diseaseen_GB
dc.titleInvolvement of nitric oxide in the nigrostriatal dopaminergic system degeneration : a study on the 6-OHDA model of Parkinson's diseaseen_GB
dc.typeconferenceObjecten_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.bibliographicCitation.conferencename58° Congresso della Società Italiana di Fisiologiaen_GB
dc.bibliographicCitation.conferenceplaceLecce, Italy, 19-21/09/2007en_GB
dc.description.reviewedpeer-revieweden_GB
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