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DC Field | Value | Language |
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dc.contributor.author | Setien-Olarra, Amaia | - |
dc.contributor.author | Marichalar-Mendia, Xabier | - |
dc.contributor.author | Fernandez-Pacheco, Juan Alonso | - |
dc.contributor.author | Fernandez-Barriales-Lopez, Marcos | - |
dc.contributor.author | Gainza-Cirauqui, Maria Luisa | - |
dc.contributor.author | Aguirre-Urizar, Jose Manuel | - |
dc.date.accessioned | 2022-03-16T08:02:38Z | - |
dc.date.available | 2022-03-16T08:02:38Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.citation | Setién-Olarra, A., Marichalar-Mendia, X., Fernández-Pacheco, J. A., Fernández-Barriales-López, M., Gainza-Cirauqui, M. L., & Aguirre-Urizar, J. M. (2019). Validation of microRNA expression profile in Oral Lichenoid Disease through cytological samples. Medicina Oral, Patología Oral y Cirugía Bucal, 24(5), e610. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/91505 | - |
dc.description.abstract | Background To validate oral exfoliative cytology in the analysis of the microRNA expression profile in Oral Lichenoid Disease (OLD). | en_GB |
dc.description.abstract | Material and Methods The expression of 13 microRNAs identified and presented by our group in a previous study was analyzed in 26 cases, 16 diagnosed as OLD and 10 controls with no oral mucosal pathology. Cytological samples from the oral mucosa obtained using an Orcellex toothbrush were analyzed using RT-qPCR and TaqMan microRNA assays. | en_GB |
dc.description.abstract | Results The aberrant expression was validated for 2 microRNAs (miR-146a-5p and miR-7-1-3p) of those previously recognized in the biopsy study. | en_GB |
dc.description.abstract | Conclusions This is the first time that oral exfoliative cytology is validated in a study of the alterations of the expression of microRNAs in OLD. The alteration of miR-146a and miR-7 compared to controls was validated. These microRNAs are associated with both inflammatory and carcinogenic phenomena that are involved in the etiopathogenesis of this potentially malignant oral disorder. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Medicina Oral S.L. | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Small interfering RNA | en_GB |
dc.subject | Lichen planus | en_GB |
dc.subject | Epigenetics | en_GB |
dc.title | Validation of microRNA expression profile in Oral Lichenoid Disease through cytological samples | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.4317/medoral.23020 | - |
dc.publication.title | Medicina Oral, Patologia Oral y Cirugia Bucal | en_GB |
Appears in Collections: | Scholarly Works - FacDenDS |
Files in This Item:
File | Description | Size | Format | |
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Validation of microRNA expression profile in Oral Lichenoid Disease through cytological samples.pdf | 324.71 kB | Adobe PDF | View/Open |
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