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DC Field | Value | Language |
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dc.date.accessioned | 2016-04-01T10:11:01Z | |
dc.date.available | 2016-04-01T10:11:01Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/9258 | |
dc.description | B.SC.(HONS)BIOMED.SCI. | en_GB |
dc.description.abstract | Platelets bear the fibrinogen receptor αIIbβ3, an integrin which is required for normal haemostasis. The human platelet antigen 1 (HPA-1) system is located at residue 33 of the αIIb component of this integrin. An amino acid change from a leucine (Leu) to a proline (Pro) occurs at this position due to a single nucleotide substitution (SNP) of a T to a C at base 196 of the ITGB3 gene coding for the αIIb protein. This results in the HPA-1a (Leu33) and HPA-1b (Pro33) alloantigens, which constitute the HPA-1 system. In the sample population studied which represented the Maltese population, the HPA-1b allele frequency was found to be 15.6 % and the HPA-1a allele frequency was found to be 84.4 %. The presence of the HPA-1b allele has been associated with myocardial infarction (MI), whilst the presence of the HPA-1a allele has been associated with autism. In rare cases in pregnancy or a blood transfusion, platelet incompatibility due to the HPA-1a and HPA-1b antigens occurs, resulting in alloantibody production against foreign HPA-1 antigens. Conditions associated with platelet incompatibility include neonatal alloimmune thrombocytopenia (NAIT), complications of NAIT, platelet transfusion refractoriness, post-transfusion purpura (PTP), and recurrent miscarriages. Thus, since the HPA-1a and HPA-1b allele frequencies of the Maltese population are similar to other European Caucasian population frequencies and African population frequencies, they may indicate similar polymorphism-associated diseases which may be studied alongside this polymorphism in the future. | en_GB |
dc.language.iso | en | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Blood platelets | en_GB |
dc.subject | Hemostasis | en_GB |
dc.title | Determining the frequency of human platelet antigen-1 polymorphisms in the Maltese population | en_GB |
dc.type | bachelorThesis | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.publisher.institution | University of Malta | en_GB |
dc.publisher.department | Faculty of Health Sciences. Department of Applied Biomedical Science | en_GB |
dc.description.reviewed | N/A | en_GB |
dc.contributor.creator | Samut Tagliaferro, Sarah | |
Appears in Collections: | Dissertations - FacHSc - 2013 Dissertations - FacHScABS - 2013 |
Files in This Item:
File | Description | Size | Format | |
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13BSAB004.pdf Restricted Access | 1.41 MB | Adobe PDF | View/Open Request a copy |
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