Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/92729
Title: Peripheral blood RNA biomarkers for cardiovascular disease from bench to bedside : a position paper from the EU-CardioRNA COST action CA17129
Authors: Vanhaverbeke, Maarten
Attard, Ritienne
Barteková, Monika
Ben-Aicha, Soumaya
Brandenburger, Timo
De Gonzalo-Calvo, David
Emanueli, Costanza
Farrugia, Rosienne
Grillari, Johannes
Hackl, Matthias
Kalocayova, Barbora
Martelli, Fabio
Scholz, Markus
Bezzina Wettinger, Stephanie
Devaux, Yvan
Authors: EU-CardioRNA COST Action (CA17129)
Keywords: RNA
Cardiovascular system -- Diseases
Cardiovascular system -- Diseases -- Diagnosis
Cardiovascular system -- Diseases -- Treatment
Issue Date: 2021
Publisher: European Society of Cardiology
Citation: Vanhaverbeke, M., Attard, R., Bartekova, M., Ben-Aicha, S., Brandenburger, T., de Gonzalo-Calvo, D., ... & Devaux, Y. (2021). Peripheral blood RNA biomarkers for cardiovascular disease from bench to bedside: A Position Paper from the EU-CardioRNA COST Action CA17129. Cardiovascular Research. DOI: https://doi.org/10.1093/cvr/cvab327
Abstract: Despite significant advances in the diagnosis and treatment of cardiovascular diseases, recent calls have emphasized the unmet need to improve precision-based approaches in cardiovascular disease. Although some studies provide preliminary evidence of the diagnostic and prognostic potential of circulating coding and non-coding RNAs, the complex RNA biology and lack of standardization have hampered the translation of these markers into clinical practice. In this position paper of the CardioRNA COST action CA17129, we provide recommendations to standardize the RNA development process in order to catalyse efforts to investigate novel RNAs for clinical use. We list the unmet clinical needs in cardiovascular disease, such as the identification of high-risk patients with ischaemic heart disease or heart failure who require more intensive therapies. The advantages and pitfalls of the different sample types, including RNAs from plasma, extracellular vesicles, and whole blood, are discussed in the sample matrix, together with their respective analytical methods. The effect of patient demographics and highly prevalent comorbidities, such as metabolic disorders, on the expression of the candidate RNA is presented and should be reported in biomarker studies. We discuss the statistical and regulatory aspects to translate a candidate RNA from a research use only assay to an in-vitro diagnostic test for clinical use. Optimal planning of this development track is required, with input from the researcher, statistician, industry, and regulatory partners.
URI: https://www.um.edu.mt/library/oar/handle/123456789/92729
Appears in Collections:Scholarly Works - FacHScABS

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