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DC Field | Value | Language |
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dc.contributor.author | Jusic, Amela | - |
dc.contributor.author | Thomas, Pınar Buket | - |
dc.contributor.author | Bezzina Wettinger, Stephanie | - |
dc.contributor.author | Doğan, Soner | - |
dc.contributor.author | Farrugia, Rosienne | - |
dc.contributor.author | Gaetano, Carlo | - |
dc.contributor.author | Güvenç Tuna, Bilge | - |
dc.contributor.author | Pinet, Florence | - |
dc.contributor.author | Robinson, Emma L. | - |
dc.contributor.author | Tual-Chalot, Simon | - |
dc.contributor.author | Stellos, Konstantinos | - |
dc.contributor.author | Devaux, Yvan | - |
dc.date.accessioned | 2022-04-01T11:14:00Z | - |
dc.date.available | 2022-04-01T11:14:00Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Jusic, A., Thomas, P. B., Wettinger, S. B., Doğan, S., Farrugia, R., Gaetano, C., ... & Devaux, Y. (2022). Noncoding RNAs in age-related cardiovascular diseases. Ageing Research Reviews, 77, 101610. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/92732 | - |
dc.description.abstract | Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult population worldwide and represent a severe economic burden and public health concern. The majority of human genes do not code for proteins. However, noncoding transcripts play important roles in ageing that significantly increases the risk for CVDs. Noncoding RNAs (ncRNAs) are critical regulators of multiple biological processes related to ageing such as oxidative stress, mitochondrial dysfunction and chronic inflammation. NcRNAs are also involved in pathophysiological developments within the cardiovascular system including arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction and heart failure. In this review article, we cover the roles of ncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Non-coding RNA | en_GB |
dc.subject | Cardiovascular system -- Diseases | en_GB |
dc.subject | Cardiovascular system -- Diseases -- Diagnosis | en_GB |
dc.subject | Cardiovascular system -- Diseases -- Treatment | en_GB |
dc.title | Noncoding RNAs in age-related cardiovascular diseases | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.arr.2022.101610 | - |
dc.publication.title | Ageing Research Reviews | en_GB |
Appears in Collections: | Scholarly Works - FacHScABS |
Files in This Item:
File | Description | Size | Format | |
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Noncoding RNAs in age-related cardiovascular diseases.pdf Restricted Access | 2.78 MB | Adobe PDF | View/Open Request a copy |
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