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DC Field | Value | Language |
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dc.contributor.author | Ayers, Duncan | - |
dc.contributor.author | Day, Philip JR | - |
dc.date.accessioned | 2015-01-19T09:44:17Z | - |
dc.date.available | 2015-01-19T09:44:17Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Malta Medical Journal. 2009, Vol.21(3), p. 13-19 | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/927 | - |
dc.description.abstract | The existence of an intrinsic biochemical pathway enabling specified regulation of gene expression was unheard of until the final years of the last decade. The identification of ribonucleic acid interference (RNAi) in mammalian cells has nowadays become of extreme importance in the field of functional genomics and translational medicine. The advent of RNAi technology has brought to the scientific research and pharmaceutical communities the ability to regulate expression of any desired gene in a reproducible manner. Consequently, such technology may be utilised in the design of novel therapeutics for clinical conditions having dys-regulated gene expression. Since most RNAi-based therapies in the drug development pipeline of pharmaceutical companies utilise short interfering RNA (siRNA), this review will focus on the role of siRNA in drug development. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Malta Medical Journal | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | RNA Interference | en_GB |
dc.subject | RNA, Small Interfering -- Treatment | en_GB |
dc.subject | Gene silencing | en_GB |
dc.title | Unlocking the potential of RNA interference as a therapeutic tool | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | - |
Appears in Collections: | MMJ, Volume 21, Issue 3 MMJ, Volume 21, Issue 3 Scholarly Works - FacM&SPat |
Files in This Item:
File | Description | Size | Format | |
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2009.Vol21.Issue3.A2.pdf | Unlocking the potential of RNA interference as a therapeutic tool | 327.07 kB | Adobe PDF | View/Open |
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