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Title: | Phenotypic and genetic markers of disease severity in a Maltese IBD cohort |
Authors: | Schembri, J. Pace, Nikolai Paul Piscopo, N. Degenhardt, F. Franke, A. Ellul, P. |
Keywords: | Crohn's disease -- Patients Crohn's disease -- Etiology Genes |
Issue Date: | 2019 |
Publisher: | Oxford University Press |
Citation: | Schembri, J., Pace, N., Piscopo, N., Degenhardt, F., Franke, A., & Ellul, P. (2019). Phenotypic and genetic markers of disease severity in a Maltese IBD cohort. Journal of Crohn's and Colitis, 13(Supplement 1), S535-S536. |
Abstract: | Background: Whilst most inflammatory bowel disease (IBD) treatment algorithms depend on disease severity classification, no formal validated definitions exist on what constitutes mild, moderate and severe ulcerative colitis (UC) and Crohn's disease (CD). Furthermore, the genetic architecture of disease severity may be distinct from that of disease susceptibility. Methods: IBD patients were compared with eachother on the basis of disease severity. For the purpose of this study severe IBD was defined as current or previous use of anti-TNF agents or surgery. Genotyping was carried out on the Illumina Immunochip platform. Patients were characterised using the Montreal classification. Results: Using our definition for disease severity resulted in more CD patients being classified as severe. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/93134 |
ISSN: | 18739946 |
Appears in Collections: | Scholarly Works - FacM&SAna |
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