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DC Field | Value | Language |
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dc.contributor.author | Farrugia, Rosienne | - |
dc.contributor.author | Xuereb-Anastasi, Angela | - |
dc.contributor.author | Bezzina Wettinger, Stephanie | - |
dc.date.accessioned | 2022-04-07T13:48:19Z | - |
dc.date.available | 2022-04-07T13:48:19Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Farrugia, R., Anastasi, A. X., & Wettinger, S. B. (2021). Regulation of splicing in cardiovascular disease. In Y. Devaux & E. L. Robinson (Eds.), Epigenetics in cardiovascular disease (pp. 163-186). Academic Press. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/93179 | - |
dc.description.abstract | Alternative splicing is a highly regulated process that enables a single gene to code for multiple isoforms of a protein. Misregulation of this crucial process can result in a wide range of human diseases, including cardiovascular disease, by the modification or loss of an important physiological protein function. In the heart, the importance of alternative splicing in posttranscriptional gene regulation is becoming increasingly evident. Here we give a brief overview of the splicing process, discuss the various mechanisms by which RNA splicing is regulated, and review the current knowledge of alternative splicing in the heart, in particular, factors controlling heart-specific alternative splicing and the role of alternative splicing in cardiovascular disease. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier Inc. | en_GB |
dc.rights | info:eu-repo/semantics/closedAccess | en_GB |
dc.subject | Cardiovascular system -- Diseases | en_GB |
dc.subject | Cardiovascular system -- Diseases -- Diagnosis | en_GB |
dc.subject | Cardiovascular system -- Diseases -- Treatment | en_GB |
dc.subject | RNA splicing | en_GB |
dc.title | Regulation of splicing in cardiovascular disease | en_GB |
dc.title.alternative | Epigenetics in cardiovascular disease | en_GB |
dc.type | bookPart | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/B978-0-12-822258-4.00013-4 | - |
Appears in Collections: | Scholarly Works - FacHScABS |
Files in This Item:
File | Description | Size | Format | |
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Regulation of splicing in cardiovascular disease.pdf Restricted Access | 3.85 MB | Adobe PDF | View/Open Request a copy |
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