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DC Field | Value | Language |
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dc.contributor.author | Toulopoulou, Timothea | - |
dc.contributor.author | Grech, Anton | - |
dc.contributor.author | Morris, Robin G. | - |
dc.contributor.author | Schulze, Katja | - |
dc.contributor.author | McDonald, Colm | - |
dc.contributor.author | Chapple, Ben | - |
dc.contributor.author | Rabe-Hesketh, Sophia | - |
dc.contributor.author | Murray, Robin M. | - |
dc.date.accessioned | 2022-04-14T07:14:13Z | - |
dc.date.available | 2022-04-14T07:14:13Z | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Toulopoulou, T., Grech, A., Morris, R. G., Schulze, K., McDonald, C., Chapple, B., ... & Murray, R. M. (2004). The relationship between volumetric brain changes and cognitive function: a family study on schizophrenia. Biological Psychiatry, 56(6), 447-453. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/93762 | - |
dc.description.abstract | Background We examined the cerebral correlates of intelligence, memory, and executive processing in 56 patients with schizophrenia or schizoaffective disorder and 90 of their nonpsychotic relatives to establish whether the pattern of structure–function relationships in these two groups was different from that in 55 control subjects. | en_GB |
dc.description.abstract | Methods Magnetic resonance imaging data were acquired, and volumetric measurements were made for whole brain, prefrontal region, lateral ventricles, third ventricle, temporal lobes, hippocampi, and cerebellum. | en_GB |
dc.description.abstract | Results In the total sample, full intelligence quotient (IQ) and verbal IQ correlated with the volume of the whole brain and right hippocampus; the latter was also associated with performance IQ. Left hippocampal size was associated with verbal IQ and, in control subjects and nonpsychotic relatives only, with estimated full IQ. Delayed verbal memory was linked to cerebellar and inversely to left hippocampal volume. Discrepancies in the relationship pattern emerged in patients with schizophrenia between left hippocampus and measures of IQ and verbal memory. | en_GB |
dc.description.abstract | Conclusions The latter data indicate a loss of a normal structure–function relationship in schizophrenia and might reflect a functional compensation occurring secondary to early neurodevelopmental impairment. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Brain -- Physiology | en_GB |
dc.subject | Schizophrenia -- Genetic aspects | en_GB |
dc.subject | Schizophrenia -- Pathophysiology | en_GB |
dc.subject | Cerebral cortex | en_GB |
dc.subject | Schizophrenia -- Diagnosis | en_GB |
dc.subject | Dissociative disorders | en_GB |
dc.title | The relationship between volumetric brain changes and cognitive function : a family study on schizophrenia | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.biopsych.2004.06.026 | - |
dc.publication.title | Biological Psychiatry | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPsy |
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