Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/93800
Title: | Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives |
Authors: | Schulze, Katja McDonald, Colm Frangou, Sophia Sham, Pak Grech, Anton Toulopoulou, Timothea Walshe, Muriel Sharma, Tonmoy Sigmundsson, Thordur Taylor, Mark Murray, Robin M. |
Keywords: | Biological psychiatry Hippocampus (Brain) -- Growth Hippocampus (Brain) -- Physiology Schizophrenia -- Genetic aspects Schizophrenia -- Pathophysiology Cerebral cortex Schizophrenia -- Diagnosis Dissociative disorders |
Issue Date: | 2003 |
Publisher: | Elsevier |
Citation: | Schulze, K., McDonald, C., Frangou, S., Sham, P., Grech, A., Toulopoulou, T., ... & Murray, R. M. (2003). Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives. Biological Psychiatry, 53(7), 562-570. |
Abstract: | Background
There is evidence for hippocampal volume loss in schizophrenia, but the etiology of this remains unclear. The aim of our study was to assess the contribution of familial liability and obstetric complications to hippocampal volume reduction in schizophrenia. Methods Hippocampal volumes were obtained using stereological methods from magnetic resonance scans performed on 35 schizophrenic probands from multiply affected families and 63 of their unaffected relatives, as well as 31 schizophrenic probands from families with no other affected members, 33 of their unaffected relatives, and 68 control subjects. Results Probands with schizophrenia, regardless of family history, had significant volume reduction of the left hippocampus. Hippocampal volume was not significantly reduced in either group of relatives. Obstetric complications were associated with left hippocampal volume reduction. Conclusions We failed to find evidence that hippocampal volume loss is associated with familial liability to schizophrenia but have confirmed the association between hippocampal volume reduction and exposure to obstetric complications. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/93800 |
Appears in Collections: | Scholarly Works - FacM&SPsy |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives.pdf Restricted Access | 109.68 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.