Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/94030
Title: Obstetric complications and dermatoglyphic abnormalities in schizophrenia : preliminary results from the Maudsley family study
Authors: Bramon, Elvira
McDonald, Colm
Walshe, Muriel
Toulopoulou, Timothea
Martin, B.
Hoyos, C.
Wickham, Harvey
Grech, Anton
Fearon, Paul
van Os, Jim
Fafianas, Lourdes
Murray, Robin
Keywords: Schizophrenia -- Case studies
Schizophrenics -- Case studies
Schizophrenia -- Genetic aspects
Manic-depressive illness -- Genetic aspects
Issue Date: 2000
Publisher: Elsevier
Citation: Bramon, E., McDonald, C., Walshe, M., Toulopoulou, T., Martin, B., Hoyos, C., ... & Murray, R. (2000). Obstetric complications and dermatoglyphic abnormalities in schizophrenia: Preliminary results from the Maudsley family study. Schizophrenia Research, 41(1), 70-70.
Abstract: Background: Dermatoglyphic ridge counts reflect ontogenic processes during the first and second trimesters of pregnancy. The ab ridge count (ABRC) in particular, has consistently been reported to be lower in schizophrenic patients compared to controls. Aims: (i) Replication of the findings on ABRC in the Maudsley family study samples. (ii) Explore the relationship between ABRC and obstetric complications (OCs). Method: We performed dermatoglyphic analysis (according to Cummins and Midlo) on 102 schizophrenics, 74 non-affected relatives and 60 unrelated controls. OCs were assessed using the Lewis-Murray scale and data were available for 85 patients and 11 of their unaffected siblings. Results: We found a trend for a lower ABRC in patients (patients mean=78.6, controls mean=81.6; 95% CI= -6.6 to 0.6; p=0.11). The ABRC in well relatives did not differ significantly from controls (relatives mean=79.0; 95% CI=-6.4 to 1.2; p=0.18). In the patients group the ABRC was negatively correlated with OCs (Spearman's rho=-0.26, p=0.05). In the unaffected siblings group this correlation was also negative but weaker and did not reach statistical significance (Spearman's rho= -0.1, p =0.79). Conclusions: Although we found a reduced mean ABRC in patients, this did not reach statistical significance. However, obstetric complications are associated with lower ABRC in patients with schizophrenia. Acknowledgement: This study was supported by The Wellcome Trust (057869Z/99).
URI: https://www.um.edu.mt/library/oar/handle/123456789/94030
ISSN: 15732509
Appears in Collections:Scholarly Works - FacM&SPsy



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