Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/94410
Title: | The interplay between pharmacogenetics, concomitant drugs and blood levels of amitriptyline and its main metabolites |
Authors: | Mifsud Buhagiar, Luana Casha, Marilyn Grech, Anton Serracino-Inglott, Anthony LaFerla, Godfrey |
Keywords: | Amitriptyline -- Therapeutic use Amitriptyline -- Metabolism -- Malta -- Case studies Depression, Mental -- Chemotherapy Cytochrome P-450 CYP2D6 -- Metabolism Cytochrome P-450 CYP2C19 |
Issue Date: | 2021 |
Publisher: | Future Medicine |
Citation: | Mifsud Buhagiar, L., Casha, M., Grech, A., Serracino Inglott, A., & LaFerla, G. (2021). The interplay between pharmacogenetics, concomitant drugs and blood levels of amitriptyline and its main metabolites. Personalized Medicine, 19(2), 113-123. |
Abstract: | Background: The research considers the impact of genotype-inferred variability on blood levels of amitriptyline and its main metabolites, as may be moderated by phenocopying. Patients & methods: CYP2D6 and CYP2C19 genotypes, and serum concentrations of amitriptyline, nortriptyline and hydroxymetabolites, were determined in 33 outpatients. Co-medications were reviewed to identify CYP inhibition risk. Results: CYP2C19 metabolizer status explained interpatient variation in nortriptyline to amitriptyline concentration ratios. The hydroxymetabolite to parent ratios increased with higher CYP2D6 activity scores and lower CYP2D6 inhibition risk. In patients at high CYP2D6 inhibition risk, the amitriptyline + nortriptyline concentration was, on average, 52% above the higher end of expected ranges. Conclusion: Practical construal of pharmacogenetics and drug interactions tantamount to aberrant metabolism can facilitate patient-tailored use of the established drug. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/94410 |
Appears in Collections: | Scholarly Works - FacM&SPsy |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
The_interplay_between_pharmacogenetics_concomitant_drugs_and_blood_levels_of_amitriptyline_and_its_main_metabolites_2021.pdf Restricted Access | 675.37 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.