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https://www.um.edu.mt/library/oar/handle/123456789/95268
Title: | Towards volumetric thresholds in RECIST 1.1 : therapeutic response assessment in hepatic metastases |
Authors: | Winter, Katharina S. Hofmann, Felix O. Thierfelder, Kolja M. Holch, Julian W. Hesse, Nina Baumann, Alena B. Modest, Dominik P. Stintzing, Sebastian Heinemann, Volker Ricke, Jens Sommer, Wieland H. D'Anastasi, Melvin |
Keywords: | Liver -- Cancer -- Tomography Liver -- Diseases -- Tomography Liver metastasis -- Case studies Liver metastasis -- Tomography Colon (Anatomy) -- Cancer -- Case studies Three-dimensional imaging in medicine |
Issue Date: | 2018 |
Publisher: | Springer |
Citation: | Winter, K. S., Hofmann, F. O., Thierfelder, K. M., Holch, J. W., Hesse, N., Baumann, A. B.,... D’Anastasi, M. (2018). Towards volumetric thresholds in RECIST 1.1: Therapeutic response assessment in hepatic metastases. European Radiology, 28(11), 4839-4848. |
Abstract: | Objectives: To empirically determine thresholds for volumetric assessment of response and progress of liver metastases in line with the unidimensional RECIST thresholds. Methods: Patients with metastatic colorectal cancer initially enrolled in a multicentre clinical phase-III trial were included. In all CTscans, the longest axial diameters and volumes of hepatic lesions were determined semi-automatically. The sum of diameters and volumes of 1, ≤2 and ≤5 metastases were compared to all previous examinations. Volumetric thresholds corresponding to RECIST: 1.1 thresholds were predicted with loess-regression. In sensitivity analysis, the concordances of proposed thresholds, weight-maximizing thresholds and thresholds from loess-regression were compared. Classification concordance for measurements of ≤2 metastases was further analyzed. Results: For measurements of ≤2 metastases, 348 patients with 629 metastases were included, resulting in 4,773 value pairs. Regression analysis yielded volumetric thresholds of -65.3% for a diameter change of -30%, and +64.6% for a diameter change of +20%. When comparing measurements of unidimensional RECIST assessment with volumetric measurements, there was a concordance of significant progress (≥+20% and ≥+65%) in 88.3% and of significant response (≤-30% and ≤-65%) in 85.0%. Conclusions: In patients with hepatic metastases, volumetric thresholds of +65% and -65% were yielded corresponding to RECIST thresholds of +20% and -30%. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/95268 |
Appears in Collections: | Scholarly Works - FacM&SCRNM |
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Towards_volumetric_thresholds_in_RECIST_1_1_therapeutic_response_assessment_in_hepatic _metastases_2018.pdf Restricted Access | 3.87 MB | Adobe PDF | View/Open Request a copy |
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