Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/95278
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nougaret, Stephanie | - |
dc.contributor.author | Lakhman, Yulia | - |
dc.contributor.author | Gönen, Mithat | - |
dc.contributor.author | Goldman, Debra A. | - |
dc.contributor.author | Miccò, Maura | - |
dc.contributor.author | D'Anastasi, Melvin | - |
dc.contributor.author | Johnson, Sarah A. | - |
dc.contributor.author | Juluru, Krishna | - |
dc.contributor.author | Arnold, Angela G. | - |
dc.contributor.author | Sosa, Ramon E. | - |
dc.contributor.author | Soslow, Robert A. | - |
dc.contributor.author | Vargas, Hebert Alberto | - |
dc.contributor.author | Hricak, Hedvig | - |
dc.contributor.author | Kauff, Noah D. | - |
dc.contributor.author | Sala, Evis | - |
dc.date.accessioned | 2022-05-06T17:07:02Z | - |
dc.date.available | 2022-05-06T17:07:02Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Nougaret, S., Lakhman, Y., Gönen, M., Goldman, D. A., Miccò, M., D’Anastasi, M.,...Sala, E. (2017). High-grade serous ovarian cancer: associations between BRCA mutation status, CT imaging phenotypes, and clinical outcomes. Radiology, 285(2), 472-481. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/95278 | - |
dc.description.abstract | Purpose: To investigate the associations between BRCA mutation status and computed tomography (CT) phenotypes of high-grade serous ovarian cancer (HGSOC) and to evaluate CT indicators of cytoreductive outcome and survival in patients with BRCA-mutant HGSOC and those with BRCA wild-type HGSOC. | en_GB |
dc.description.abstract | Materials and Methods: This HIPAA-compliant, institutional review board–approved retrospective study included 108 patients (33 with BRCA mutant and 75 with BRCA wild-type HGSOC) who underwent CT before primary debulking. Two radiologists independently reviewed the CT findings for various qualitative CT features. Associations between CT features, BRCA mutation status, cytoreductive outcome, and progression-free survival (PFS) were evaluated by using logistic regression and Cox proportional hazards regression, respectively. | en_GB |
dc.description.abstract | Results: Peritoneal disease (PD) pattern, presence of PD in gastrohepatic ligament, mesenteric involvement, and supradiaphragmatic lymphadenopathy at CT were associated with BRCA mutation status (multiple regression: P , .001 for each CT feature). While clinical and CT features were not associated with cytoreductive outcome for patients with BRCA-mutant HGSOC, presence of PD in lesser sac (odds ratio [OR] = 2.40) and left upper quadrant (OR = 1.19), mesenteric involvement (OR = 7.10), and lymphadenopathy in supradiaphragmatic (OR = 2.83) and suprarenal para-aortic (OR = 4.79) regions were associated with higher odds of incomplete cytoreduction in BRCA wild-type HGSOC (multiple regression: P , .001 each CT feature). Mesenteric involvement at CT was associated with significantly shorter PFS for both patients with BRCA-mutant HGSOC (multiple regression: hazard ratio [HR] = 26.7 P , .001) and those with BRCA wild-type HGSOC (univariate analysis: reader 1, HR = 2.42, P , .001; reader 2, HR = 2.61; P , .001). | en_GB |
dc.description.abstract | Conclusion: Qualitative CT features differed between patients with BRCA-mutant HGSOC and patients with BRCA wild-type HGSOC. CT indicators of cytoreductive outcome varied according to BRCA mutation status. Mesenteric involvement at CT was an indicator of significantly shorter PFS for both patients with BRCA-mutant HGSOC and those with BRCA wild-type HGSOC. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Radiological Society of North America | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Ovaries -- Cancer -- Diagnosis | en_GB |
dc.subject | Ovaries -- Cancer -- Case studies | en_GB |
dc.subject | Ovaries -- Cancer -- Tomography | en_GB |
dc.subject | Breast -- Cancer -- Diagnosis | en_GB |
dc.subject | BRCA genes -- Diagnostic use | en_GB |
dc.subject | Peritoneal diseases | en_GB |
dc.title | High-grade serous ovarian cancer : associations between BRCA mutation status, CT imaging phenotypes, and clinical outcomes | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1148/radiol.2017161697 | - |
dc.publication.title | Radiology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SCRNM |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
High_grade_serous_ovarian_cancer_associations_between_BRCA_mutation_status_CT_imaging_phenotypes_and_clinical_outcomes_2017.pdf Restricted Access | 705.38 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.