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Title: | Improved detection of a tumorous involvement of the mesorectal fascia and locoregional lymph nodes in locally advanced rectal cancer using DCE-MRI |
Authors: | Armbruster, Marco D'Anastasi, Melvin Holzner, Veronika Kreis, Martin E. Dietrich, Olaf Brandlhuber, Bernhard Graser, Anno Brandlhuber, Martina |
Keywords: | Rectum -- Cancer -- Diagnosis Rectum -- Magnetic resonance imaging Contrast-enhanced magnetic resonance imaging |
Issue Date: | 2018 |
Publisher: | Springer |
Citation: | Armbruster, M., D’Anastasi, M., Holzner, V., Kreis, M. E., Dietrich, O., Brandlhuber, B.,...Brandlhuber, M. (2018). Improved detection of a tumorous involvement of the mesorectal fascia and locoregional lymph nodes in locally advanced rectal cancer using DCE-MRI. International Journal of Colorectal Disease, 33(7), 901-909. |
Abstract: | Purpose: The prediction of an infiltration of the mesorectal fascia (MRF) and malignant lymph nodes is essential for treatment
planning and prognosis of patients with rectal cancer. The aim of this study was to assess the additional diagnostic value of
dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for the detection of a malignant involvement of the MRF
and of mesorectal lymph nodes in patients with locally advanced rectal cancer. Methods: In this prospective study, 22 patients with locally advanced rectal cancer were examined with 1.5-T MRI between September 2012 and April 2015. Histopathological assessment of tumor size, tumor infiltration to the MRF, and malignant involvement of locoregional lymph nodes served as standard of reference. Sensitivity and specificity of detecting MRF infiltration and malignant nodes (nodal cut-off size [NCO] ≥ 5 and ≥ 10mm, respectively) was determined by conventionalMRI (cMRI; precontrast and postcontrast T1-weighted, T2-weighted, and diffusion-weighted images) and by additional semi-quantitative DCE-MRI maps (cMRI+DCE-MRI). Results: Compared to cMRI, additional semi-quantitative DCE-MRI maps significantly increased sensitivity (86 vs. 71% [NCO ≥ 5 mm]/29% [NCO ≥ 10 mm]) and specificity (90 vs. 70% [NCO ≥ 5 mm]) of detecting malignant lymph nodes (p < 0.05). Moreover, DCE-MRI significantly augmented specificity (91 vs. 82%) of discovering a MRF infiltration (p < 0.05), while there was no change in sensitivity (83%; p > 0.05). Conclusion: DCE-MRI considerably increases both sensitivity and specificity for the detection of small mesorectal lymph node metastases (≥ 5 mm but < 10 mm) and sufficiently improves specificity of a suspected MRF infiltration in patients with locally advanced rectal cancer. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/95311 |
Appears in Collections: | Scholarly Works - FacM&SCRNM |
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Improved_detection_of_a_tumorous_involvement_of_the_mesorectal_fascia_and_locoregional_lymph_nodes_2018.pdf Restricted Access | 10.83 MB | Adobe PDF | View/Open Request a copy |
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