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DC Field | Value | Language |
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dc.contributor.author | Schuurman, Alex R. | - |
dc.contributor.author | Reijnders, Tom D. Y. | - |
dc.contributor.author | Saris, Anno | - |
dc.contributor.author | Ramirez Moral, Ivan | - |
dc.contributor.author | Schinkel, Michiel | - |
dc.contributor.author | Brabander, Justin de | - |
dc.contributor.author | Linge, Christine van | - |
dc.contributor.author | Vermeulen, Louis | - |
dc.contributor.author | Scicluna, Brendon P. | - |
dc.contributor.author | Joost Wiersinga, W. | - |
dc.contributor.author | Vieira Braga, Felipe A. | - |
dc.contributor.author | Poll, Tom van der | - |
dc.date.accessioned | 2022-05-24T13:06:04Z | - |
dc.date.available | 2022-05-24T13:06:04Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Schuurman, A. R., Reijnders, T. D., Saris, A., Moral, I. R., Schinkel, M., de Brabander, J., ... & van der Poll, T. (2021). Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia. Elife, 10, e69661. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/96322 | - |
dc.description.abstract | The exact immunopathophysiology of community-acquired pneumonia (CAP) caused by SARS-CoV-2 (COVID-19) remains clouded by a general lack of relevant disease controls. The scarcity of single-cell investigations in the broader population of patients with CAP renders it difficult to distinguish immune features unique to COVID-19 from the common characteristics of a dysregulated host response to pneumonia. We performed integrated single-cell transcriptomic and proteomic analyses in peripheral blood mononuclear cells from a matched cohort of eight patients with COVID-19, eight patients with CAP caused by Influenza A or other pathogens, and four non-infectious control subjects. Using this balanced, multi-omics approach, we describe shared and diverging transcriptional and phenotypic patterns-including increased levels of type I interferon-stimulated natural killer cells in COVID-19, cytotoxic CD8 T EMRA cells in both COVID-19 and influenza, and distinctive monocyte compositions between all groups-and thereby expand our understanding of the peripheral immune response in different etiologies of pneumonia. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | eLife Sciences Publications Ltd. | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | COVID-19 (Disease) | en_GB |
dc.subject | Pneumonia -- Diagnosis | en_GB |
dc.subject | Human beings | en_GB |
dc.subject | Immunology | en_GB |
dc.subject | Communicable diseases -- Case studies | en_GB |
dc.subject | Inflammation | en_GB |
dc.subject | Microbiology -- Case studies | en_GB |
dc.title | Integrated single-cell analysis unveils diverging immune features of COVID-19, influenza, and other community-acquired pneumonia | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.7554/eLife.69661 | - |
dc.publication.title | eLife | en_GB |
Appears in Collections: | Scholarly Works - FacHScABS |
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Integrated_single_cell_analysis_unveils_diverging_immune_features_of_COVID_19_influenza_and_other_community_acquired_pneumonia.pdf | 6.32 MB | Adobe PDF | View/Open |
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