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DC Field | Value | Language |
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dc.contributor.author | Meijer, Mariska T. | - |
dc.contributor.author | Vos, Alex F. de | - |
dc.contributor.author | Scicluna, Brendon P. | - |
dc.contributor.author | Roelofs, Joris J. T. H. | - |
dc.contributor.author | Abou Fayçal, Chérine | - |
dc.contributor.author | Orend, Gertraud | - |
dc.contributor.author | Uhel, Fabrice | - |
dc.contributor.author | Poll, Tom van der | - |
dc.date.accessioned | 2022-05-24T14:51:15Z | - |
dc.date.available | 2022-05-24T14:51:15Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Meijer, M. T., de Vos, A. F., Scicluna, B. P., Roelofs, J. J., Abou Fayçal, C., Orend, G., ... & van der Poll, T. (2021). Tenascin-C deficiency is associated with reduced bacterial outgrowth during Klebsiella pneumoniae-evoked pneumosepsis in mice. Frontiers in Immunology, 12, 600979. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/96345 | - |
dc.description.abstract | Tenascin C (TNC) is an extracellular matrix glycoprotein that recently emerged as an immunomodulator. TNC-deficient (TNC-/-) mice were reported to have a reduced inflammatory response upon systemic administration of lipopolysaccharide, the toxic component of gram-negative bacteria. Here, we investigated the role of TNC during gram-negative pneumonia derived sepsis. TNC+/+ and TNC-/- mice were infected with Klebsiella pneumoniae via the airways and sacrificed 24 and 42 h thereafter for further analysis. Pulmonary TNC protein levels were elevated 42 h after infection in TNC+/+ mice and remained undetectable in TNC-/- mice. TNC-/- mice showed modestly lower bacterial loads in lungs and blood, and a somewhat reduced local-but not systemic-inflammatory response. Moreover, TNC-/- and TNC+/+ mice did not differ with regard to neutrophil recruitment, lung pathology or plasma markers of distal organ injury. These results suggest that while TNC shapes the immune response during lipopolysaccharide-induced inflammation, this role may be superseded during pneumosepsis caused by a common gram-negative pathogen. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Research Foundation | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Tenascin -- Physiological effect | en_GB |
dc.subject | Septicemia -- Diagnosis | en_GB |
dc.subject | Klebsiella pneumoniae | en_GB |
dc.subject | Pneumonia -- Diagnosis | en_GB |
dc.subject | Natural immunity | en_GB |
dc.subject | Immune system | en_GB |
dc.subject | Mice as laboratory animals | en_GB |
dc.title | Tenascin-C deficiency is associated with reduced bacterial outgrowth during Klebsiella pneumoniae-evoked pneumosepsis in mice | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3389/fimmu.2021.600979 | - |
dc.publication.title | Frontiers in Immunology | en_GB |
Appears in Collections: | Scholarly Works - FacHScABS |
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Tenascin_C_deficiency_is_associated_with_reduced_bacterial_outgrowth_during_klebsiella_pneumoniae_evoked_pneumosepsis_in_mice.pdf | 1.78 MB | Adobe PDF | View/Open |
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