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DC Field | Value | Language |
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dc.date.accessioned | 2022-05-26T05:52:45Z | - |
dc.date.available | 2022-05-26T05:52:45Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Sammut, L. (2021). Probing the solid-state behaviour of pharmaceuticals under different environmental conditions (Master’s dissertation). | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/96430 | - |
dc.description | M.Sc.(Melit.) | en_GB |
dc.description.abstract | The aim of this study is to understand the solid-state properties of imatinib, the free base of imatinib mesylate (Gleevec ®), an active pharmaceutical ingredient (API) that is used to treat chronic myelogenous leukaemia under different environmental conditions using crystal engineering techniques. The behaviour of imatinib after grinding with acidic co-crystal formers was studied, where the API’s solubility was measured in water using UV-Vis techniques. The solubility of imatinib in water improved significantly when ground with acidic co-crystal formers and when ground with pyridoxine. Imatinib free base was recrystallised from several solvents and solvent mixtures, from which one major polymorphic form was detected. The unit cell parameters as well as the atomic co-ordinates were determined. The crystal structure of imatinib free base has been determined but further parameters are still required. Rietveld refinement would be required so that any differences between the experimental powder pattern and modelled crystal data are minimised. This process would validate the structure solution which can eventually be published. | en_GB |
dc.language.iso | en | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Imatinib | en_GB |
dc.subject | Leukemia -- Treatment | en_GB |
dc.subject | Molecules | en_GB |
dc.subject | Polymorphism (Crystallography) | en_GB |
dc.subject | Crystals | en_GB |
dc.subject | Solid state chemistry | en_GB |
dc.title | Probing the solid-state behaviour of pharmaceuticals under different environmental conditions | en_GB |
dc.type | masterThesis | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.publisher.institution | University of Malta | en_GB |
dc.publisher.department | Faculty of Science. Department of Chemistry | en_GB |
dc.description.reviewed | N/A | en_GB |
dc.contributor.creator | Sammut, Luke (2021) | - |
Appears in Collections: | Dissertations - FacSci - 2021 Dissertations - FacSciChe - 2021 |
Files in This Item:
File | Description | Size | Format | |
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Luke Sammut.pdf Restricted Access | 4.06 MB | Adobe PDF | View/Open Request a copy |
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