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DC Field | Value | Language |
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dc.contributor.author | Brands, Xanthe | - |
dc.contributor.author | Haak, Bastiaan W. | - |
dc.contributor.author | Klarenbeek, Augustijn M. | - |
dc.contributor.author | Otto, Natasja A. | - |
dc.contributor.author | Faber, Daniël R. | - |
dc.contributor.author | Lutter, René | - |
dc.contributor.author | Scicluna, Brendon P. | - |
dc.contributor.author | Joost Wiersinga, W. | - |
dc.contributor.author | Poll, Tom van der | - |
dc.date.accessioned | 2022-05-27T05:27:13Z | - |
dc.date.available | 2022-05-27T05:27:13Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Brands, X., Haak, B. W., Klarenbeek, A. M., Otto, N. A., Faber, D. R., Lutter, R., ... & van der Poll, T. (2020). Concurrent immune suppression and hyperinflammation in patients with community-acquired pneumonia. Frontiers in Immunology, 11, 796. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/96511 | - |
dc.description.abstract | Background: The nature and timing of the host immune response during infections remain uncertain and most knowledge is derived from critically ill sepsis patients. We aimed to test the hypothesis that community-acquired pneumonia (CAP) is associated with concurrent immune suppression and systemic inflammation. | en_GB |
dc.description.abstract | Methods: Blood was collected from 79 CAP patients within 24 h after hospitalization and 1 month after discharge; 42 age- and sex-matched subjects without acute infection served as controls. Blood leukocytes were stimulated with lipopolysaccharide (LPS) or Klebsiella pneumoniae, and cytokines were measured in supernatants. Fifteen plasma biomarkers reflective of key host response pathways were compared between CAP patients with the strongest immune suppression (lowest 25% blood leukocyte tumor necrosis factor (TNF)-α production in response to LPS) and those with the least immune suppression (highest 25% of LPS-induced TNF-α production). | en_GB |
dc.description.abstract | Results: Blood leukocytes of CAP patients (relative to control subjects) showed a reduced capacity to release TNF-α, interleukin (IL)-1β, IL-6 and IL-10 upon stimulation with LPS or K. pneumoniae, with a concurrently enhanced ability to release the anti-inflammatory mediator IL-1 receptor antagonist, irrespective of the presence of sepsis (18.9% of cases). Low (relative to high) TNF-α producers displayed higher plasma levels of biomarkers reflecting systemic inflammation, neutrophil degranulation, endothelial cell activation, a disturbed vascular barrier function and coagulation activation. | en_GB |
dc.description.abstract | Conclusion: CAP replicates a common feature of immune suppression in sepsis. The coexistence of immune suppression and hyperinflammation in CAP argues against the theory of two distinct phases during the host response to sepsis. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Research Foundation | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Community-acquired pneumonia | en_GB |
dc.subject | Immunosuppression | en_GB |
dc.subject | Inflammation -- Immunological aspects | en_GB |
dc.subject | Septicemia -- Diagnosis | en_GB |
dc.subject | Endotoxins -- Analysis | en_GB |
dc.title | Concurrent immune suppression and hyperinflammation in patients with community-acquired pneumonia | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3389/fimmu.2020.00796 | - |
dc.publication.title | Frontiers in Immunology | en_GB |
Appears in Collections: | Scholarly Works - FacHScABS |
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File | Description | Size | Format | |
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Concurrent_immune_suppression_and_hyperinflammation_in_patients_with_community_acquired_pneumonia.pdf | 2.2 MB | Adobe PDF | View/Open |
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