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https://www.um.edu.mt/library/oar/handle/123456789/96526
Title: | The changing landscape of treatment options in childhood acute lymphoblastic leukaemia |
Authors: | Micallef, Benjamin Nisticò, Robert Sarac, Sinan B. Bjerrum, Ole W. Butler, Dianne Sammut Bartolo, Nicolette Serracino-Inglott, Anthony Borg, John Joseph |
Keywords: | Cancer research Human genetics Lymphoblastic leukemia Lymphoblastic leukemia in children Lymphoblastic leukemia in children -- Treatment |
Issue Date: | 2022 |
Publisher: | Elsevier |
Citation: | Micallef, B., Nistico, R. G., Sarac, S. B., Bjerrum, O. W., Butler, D., Sammut-Bartolo, N., ... & Borg, J. J. (2022). The changing landscape of treatment options in childhood acute lymphoblastic leukaemia. Drug Discovery Today, 27(5), 1483-1494. |
Abstract: | New paediatric acute lymphoblastic leukaemia (ALL) treatments have been developed and innovative products are in the pipeline. However, despite many active clinical trials, bridging bench science to clinical development to authorised medicines remains challenging. Research in first-line treatment continues to focus on multidrug chemotherapy with the potential addition of new targeted molecules being studied. Research in second- and third-line treatment represents a shift from cytotoxic intensification to an area of precision medicine through emergent innovative and immuno-oncology products. The collaborative research model in ALL involving different stakeholders should intensify to facilitate bench-to-bedside clinical translation for the benefit of patients. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/96526 |
Appears in Collections: | Scholarly Works - FacM&SPha |
Files in This Item:
File | Description | Size | Format | |
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The changing landscape of treatment options in childhood acute lymphoblastic leukaemia.pdf Restricted Access | 5.02 MB | Adobe PDF | View/Open Request a copy |
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