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DC Field | Value | Language |
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dc.contributor.author | Akbar Sheikh, Fatima | - |
dc.contributor.author | Aamir, Muhammad Naeem | - |
dc.contributor.author | Haseeb, Muhammad Tahir | - |
dc.contributor.author | Shah, Muhammad Ajmal | - |
dc.contributor.author | Farid-ul-Haq, Muhammad | - |
dc.contributor.author | Alqarn, Mohammed | - |
dc.contributor.author | Vargas-De-La-Cruz, Celia | - |
dc.contributor.author | Blundell, Renald | - |
dc.date.accessioned | 2022-05-27T06:41:30Z | - |
dc.date.available | 2022-05-27T06:41:30Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Akbar Sheikh, F., Aamir, M. N., Haseeb, M. T., Shah, M. A., Farid-ul-Haq, M., Alqarn, M., ...Blundell, R. (2022). Appraisal of the pharmacokinetic profile, histopathology, and stability studies of a fast dissolving oral film based on natural polysaccharide. Pakistan Journal of Pharmaceutical Sciences, 35(3), 937-944. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/96527 | - |
dc.description.abstract | The present research is designed to evaluate the pharmacokinetic profile, histological evaluation, and stability studies of an orodispersible film (ODF) of tizanidine (TZ) and meloxicam (MX) prepared from a natural polysaccharide, i.e., xanthan gum. In vivo release study of TZ and MX was performed in rabbits and results indicated the better pharmacokinetics parameters and improved the oral bioavailability when compared to the oral aqueous suspension and solution of TZ and MX, respectively. The intermediate stability studies were performed at 30±2°C and 65±5% RH, whereas, the accelerated stability studies were carried out at 40±2°C and 75±5% RH, respectively for the duration of six months and results indicated that the ODF was stable for six months without any substantial difference in essential physico-chemical parameters, mechanical attributes, and morphological constraints. The toxicity profile of ODF was determined through histopathology of vital organs after administering the ODF to the rabbits. Histopathology revealed that the tissues of all vital organs are normal and did not exhibit any abnormalities, lesions, or hemorrhage. Therefore, the ODF prepared from xanthan gum exhibited a non-toxic and stable formulation with a better pharmacokinetics profile of MX and TZ. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Bahauddin Zakariya University | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Polysaccharides -- Synthesis | en_GB |
dc.subject | Biomathematics | en_GB |
dc.subject | Histology, Pathological | en_GB |
dc.title | Appraisal of the pharmacokinetic profile, histopathology, and stability studies of a fast dissolving oral film based on natural polysaccharide | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.36721/PJPS.2022.35.3.SP.937-944.1 | - |
dc.publication.title | Pakistan Journal of Pharmaceutical Sciences | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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Appraisal of the pharmacokinetic profile.pdf Restricted Access | 860.22 kB | Adobe PDF | View/Open Request a copy |
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