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DC Field | Value | Language |
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dc.contributor.author | Scicluna, Brendon P. | - |
dc.contributor.author | Remme, Carol Ann | - |
dc.contributor.author | Rivaud, Mathilde | - |
dc.contributor.author | Wilde, Arthur A. M. | - |
dc.contributor.author | Bezzina, Connie R. | - |
dc.contributor.author | Verkerk, Arie O. | - |
dc.date.accessioned | 2022-06-09T04:47:54Z | - |
dc.date.available | 2022-06-09T04:47:54Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Scicluna, B. P., Remme, C. A., Rivaud, M., Wilde, A. A., Bezzina, C. R., & Verkerk, A. O. (2015). Chemokine ligand 9 modulates cardiac repolarization via Cxcr3 receptor binding. International Journal of Cardiology, 201, 49-52. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/97341 | - |
dc.description.abstract | Inflammation influences various disease etiologies and evidence is accumulating that it may also affect risk for arrhythmia and sudden cardiac death [1], [2], [3]. However, knowledge concerning the underlying mechanisms is scarce, and while a direct effect of inflammatory mediators on cardiomyocyte electrophysiological properties is plausible, this is as yet unexplored. The possibility of a direct effect of inflammatory mediators on cardiomyocte electrical properties draws support from previous findings in neurons, where cytokines and chemokines have been recognized as modulators of neuronal excitability. Here, we studied the direct functional effects of chemokine (C-X-C motif) ligand 9 (Cxcl9), a small type-II interferon inducible chemotactic factor that signals via the G-protein coupled receptor Cxcr3, on the electrophysiological properties of mouse ventricular myocytes. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier Ireland Ltd. | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Action potentials (Electrophysiology) | en_GB |
dc.subject | Chemokines -- Immunology | en_GB |
dc.subject | Membrane potentials (Electrophysiology) | en_GB |
dc.subject | Muscle cells | en_GB |
dc.subject | Protein binding -- Research | en_GB |
dc.title | Chemokine ligand 9 modulates cardiac repolarization via Cxcr3 receptor binding | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.ijcard.2015.07.096 | - |
dc.publication.title | International Journal of Cardiology | en_GB |
Appears in Collections: | Scholarly Works - FacHScABS |
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