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DC Field | Value | Language |
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dc.contributor.author | Uhel, Fabrice | - |
dc.contributor.author | Peters-Sengers, Hessel | - |
dc.contributor.author | Falahi, Fahimeh | - |
dc.contributor.author | Scicluna, Brendon P. | - |
dc.contributor.author | Vught, Lonneke A. van | - |
dc.contributor.author | Bonten, Marc M.J. | - |
dc.contributor.author | Cremer, Olaf L. | - |
dc.contributor.author | Schultz, Marcus J. | - |
dc.contributor.author | Poll, Tom van der | - |
dc.date.accessioned | 2022-06-09T06:34:41Z | - |
dc.date.available | 2022-06-09T06:34:41Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Uhel, F., Peters-Sengers, H., Falahi, F., Scicluna, B. P., van Vught, L. A., Bonten, M. J., ... & van der Poll, T. (2020). Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study. Intensive Care Medicine, 46(8), 1576-1589. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/97358 | - |
dc.description.abstract | Purpose: Sepsis is the most frequent cause of acute kidney injury (AKI). The "Acute Disease Quality Initiative Workgroup" recently proposed new definitions for AKI, classifying it as transient or persistent. We investigated the incidence, mortality, and host response aberrations associated with transient and persistent AKI in sepsis patients. | en_GB |
dc.description.abstract | Methods: A total of 1545 patients admitted with sepsis to 2 intensive care units in the Netherlands were stratified according to the presence (defined by any urine or creatinine RIFLE criterion within the first 48 h) and evolution of AKI (with persistent defined as remaining > 48 h). We determined 30-day mortality by logistic regression adjusting for confounding variables and analyzed 16 plasma biomarkers reflecting pathways involved in sepsis pathogenesis (n = 866) and blood leukocyte transcriptomes (n = 392). | en_GB |
dc.description.abstract | Results: AKI occurred in 37.7% of patients, of which 18.4% was transient and 81.6% persistent. On admission, patients with persistent AKI had higher disease severity scores and more frequently had severe (injury or failure) RIFLE AKI stages than transient AKI patients. Persistent AKI, but not transient AKI, was associated with increased mortality by day 30 and up to 1 year. Persistent AKI was associated with enhanced and sustained inflammatory and procoagulant responses during the first 4 days, and a more severe loss of vascular integrity compared with transient AKI. Baseline blood gene expression showed minimal differences with respect to the presence or evolution of AKI. | en_GB |
dc.description.abstract | Conclusion: Persistent AKI is independently associated with sepsis mortality, as well as with sustained inflammatory and procoagulant responses, and loss of vascular integrity as compared with transient AKI. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Springer | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Acute renal failure -- Diagnosis | en_GB |
dc.subject | Host-virus relationships | en_GB |
dc.subject | Intensive care units | en_GB |
dc.subject | Mortality -- Case studies | en_GB |
dc.subject | Septicemia -- Diagnosis | en_GB |
dc.title | Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort study | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.contributor.corpauthor | MARS Consortium | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1007/s00134-020-06119-x | - |
dc.publication.title | Intensive Care Medicine | en_GB |
Appears in Collections: | Scholarly Works - FacHScABS |
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Mortality_and_host_response_aberrations_associated_with_transient_and_persistent_acute_kidney_injury_in_critically_ill_patients_with_sepsis.pdf | 6.29 MB | Adobe PDF | View/Open |
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