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https://www.um.edu.mt/library/oar/handle/123456789/97532
Title: | Hepatitis B vaccinees may be mistaken for confirmed hepatitis B surface antigen-positive blood donors |
Authors: | Dow, B. C. Yates, Philip Galea, George Munro, H. Buchanan, I. Ferguson, K. |
Keywords: | Hepatitis B -- Vaccination Antigens Blood donors |
Issue Date: | 2002 |
Publisher: | Blackwell Science |
Citation: | Dow, B. C., Yates, P., Galea, G., Munro, H., Buchanan, I., & Ferguson, K. (2002). Hepatitis B vaccinees may be mistaken for confirmed hepatitis B surface antigen‐positive blood donors. Vox Sanguinis, 82, 15-17. |
Abstract: | Background and Objectives: Hepatitis B surface antigen (HBsAg) test sensitivities have gradually increased, and neutralizable weak HBsAg-positive donations, with no other hepatitis B virus (HBV) markers, have occasionally been found in our donor population. On investigation, these donors have admitted to receiving hepatitis B vaccine up to 5 days previously. A study was therefore initiated to monitor HBsAg reactivity amongst volunteers after receiving their first dose of hepatitis B vaccine. Materials and Methods: Eight volunteers were tested using three HBsAg assays (Abbott Auszyme, Ortho HBsAg-3 and Abbott/Murex GE34/36) on days 0, 3, 5, 7 and 10 after administration of hepatitis B vaccine. Results: Two HBsAg tests (Abbott Auszyme and Ortho HBsAg-3) did not detect HBsAg reactivity amongst the volunteers, although the Abbott Auszyme test results reached 70–80% of the manufacturer’s cut-off at day 3 in two volunteers. The most recently launched assay (Abbott/Murex GE 34/36) detected seven (87%) of the eight volunteers as HBsAg reactive on day 3, and two (25%) volunteers were still reactive on day 5. Conclusion: The Abbott/Murex GE 34/36 assay demonstrated HBsAg reactivity in most volunteers on day 3 and in some on day 5 after vaccination. It is therefore recommended that individuals who have recently been vaccinated with hepatitis B be deferred from blood donation for at least 7 days. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/97532 |
Appears in Collections: | Scholarly Works - FacM&SPat |
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Hepatitis_B_vaccinees_may_be_mistaken_for_confirmed_hepatitis_B_surface_antigen_positive_blood_donors_2002.pdf Restricted Access | 159.41 kB | Adobe PDF | View/Open Request a copy |
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