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Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/98495
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dc.contributor.authorBaron, Byron-
dc.date.accessioned2022-06-27T11:06:50Z-
dc.date.available2022-06-27T11:06:50Z-
dc.date.issued2012-
dc.identifier.citationBaron, B. (2014). Breaking the silence : The interplay between transcription factors and DNA methylation. In A .Dric (Ed.), Methylation (pp.1-26). Intechopen.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/98495-
dc.description.abstractDNA methylation is best known for its role in gene silencing through a methyl group (CH3) being added to the 5' carbon of cytosine bases (giving 5-methylcytosine) in the promoters of genes leading to supression of transcription. De novo methylation, which involves the addition of a methyl group to unmodified DNA, is described as an epigenetic change because it is a chemical modification to DNA not a change brought about by a DNA mutation. Unlike mutations, methylation changes are potentially reversible. Epigenetic changes also include changes to DNA-associated molecules such as histone modifications, chromatin-remodelling complexes and other small non-coding RNAs including miRNAs and siRNAs. These changes have key roles in imprinting (gene-ex‐ pression dependent on parental origin), X chromosome inactivation and heterochromatin formation among others [3-5].en_GB
dc.language.isoenen_GB
dc.publisherIntechopenen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectMethylationen_GB
dc.subjectDNAen_GB
dc.subjectCell biologyen_GB
dc.subjectEpigeneticsen_GB
dc.subjectDevelopmental biologyen_GB
dc.subjectHuman genomeen_GB
dc.titleBreaking the silence : the interplay between transcription factors and DNA methylationen_GB
dc.title.alternativeMethylationen_GB
dc.typebookParten_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.5772/55021-
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