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Title: | Biochemical dysregulation of pre-eclampsia and gestational diabetes mellitus |
Other Titles: | Prediction of maternal and fetal syndrome of preeclampsia |
Authors: | Portelli, Maria Baron, Byron |
Keywords: | Inflammation Oxidative stress Vascular endothelial growth factors Insulin resistance Endothelium Diabetes -- Risk factors Preeclampsia |
Issue Date: | 2019 |
Publisher: | IntechOpen |
Citation: | Portelli, M., & Baron, B. (2019). Biochemical dysregulation of pre-eclampsia and gestational diabetes mellitus. In N. Sharma (Ed.), Prediction of maternal and fetal syndrome of preeclampsia. London: IntechOpen. |
Abstract: | Emerging evidence indicates that among the various pregnancy complications, pre-eclampsia and gestational diabetes mellitus (GDM) seem to have, at least in part, shared underlying ethiologies. Apart from sharing numerous risk factors, it has been shown that the rate of pre-eclampsia is influenced by the presence and severity of GDM, with hyperglycemia due to insulin resistance and the biochemical changes this brings about (angiogenic imbalance, oxidative stress and inflammation), playing some role in the pathogenesis of endothelial dysfunction leading to the development of pre-eclampsia. However, so far the biochemical mechanisms underlying and linking these two conditions is still not properly understood. The altered physiological parameters, dysregulation of potential protein biomarkers and DNA-related changes (mutations, methylations, miRNAs) will be combined in this review to explore possible underlying mechanisms. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/98496 |
Appears in Collections: | Scholarly Works - CenMMB |
Files in This Item:
File | Description | Size | Format | |
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Biochemical_Dysregulation_of_Pre-Eclampsia_and_Gestational_Diabetes_Mellitus(2019).pdf | 994.41 kB | Adobe PDF | View/Open |
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