Formation of carbon-carbon bond via nitroalkanes under heterogeneous catalyst

Abstract

Nitroalkanes are very important starting material in the formation of carbon-carbon bond. Under basic conditions, the nitronate union can react with saturated or conjugated carbonyl compounds, nitroaldol (Henry) or Michael reaction, respectively, leading to 1,2- and 1,4-difunctionalized derivatives. These reactions are routinely performed under homogeneous solution of the reactants in an organic solvent using soluble bases, but, different drawbacks are often observed following these conditions. In the recent years there has been a tremendous upsurge of interest in various chemical transformations mediated by heterogeneous catalysis. In fact under heterogeneous catalyst chemical reactions can occur with better efficiency, higher purity of the products, and an easier work-up. In this context, recently, different heterogeneous catalyses have been successfully employed for the formation of C-C bond (Henry and Michael reaction) via nitroalkanes.