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Title: | Modulation of non-adrenergic non-cholinergic inhibitory transmission in rat duodenum : role of opiates and 5-hydroxytryptamine |
Authors: | Postorino, A. Serio, Rosa Mule, Flava Adamo, E. B. Di Giovanni, Giuseppe Marini, Rolando |
Keywords: | Receptor, Serotonin, 5-HT Rats as laboratory animals Opioids |
Issue Date: | 1993 |
Publisher: | Univerista di Pisa |
Citation: | Postorino, A., Serio, R., Mule, F., Adamo, E. B., Di Giovanni, G., & Marini, R. (1993). Modulation of non-adrenergic non-cholinergic inhibitory transmission in rat duodenum : role of opiates and 5-hydroxytryptamine. Archives Italiennes de Biologie, 131, 235-243. |
Abstract: | In rat duodenal segments in vitro, electrical field stimulation induced a TTX-sensitive relaxation in the presence of atropine and guanethidine. A correlation between the amplitude of the evoked response and stimulus frequency was observed. Opioid peptides DAGO, DPDPE and DYN caused a dose-dependent increase in the amplitude of the response to EFS. Naloxone shifted to the right the dose-response curves for each opioid peptide significantly enhancing the ED50 values. The amplitude of the response to EFS was enhanced, dose-dependently, also in the presence of 5-HT. Such an effect induced by 5-HT was prevented by 5-HT receptor desensitization, but persisted unchanged after naloxone pretreatment. Opioids failed to affect the response to EFS after 5-HT receptor desensitization. Results suggest that in rat duodenum opioids modulate NANC inhibitory neurotransmission, indirectly the release of 5-HT. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/22774 |
Appears in Collections: | Scholarly Works - FacM&SPB |
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826-1012-1-PB.pdf Restricted Access | 1.52 MB | Adobe PDF | View/Open Request a copy |
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