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https://www.um.edu.mt/library/oar/handle/123456789/927
Title: | Unlocking the potential of RNA interference as a therapeutic tool |
Authors: | Ayers, Duncan Day, Philip JR |
Keywords: | RNA Interference RNA, Small Interfering -- Treatment Gene silencing |
Issue Date: | 2009 |
Publisher: | Malta Medical Journal |
Citation: | Malta Medical Journal. 2009, Vol.21(3), p. 13-19 |
Abstract: | The existence of an intrinsic biochemical pathway enabling specified regulation of gene expression was unheard of until the final years of the last decade. The identification of ribonucleic acid interference (RNAi) in mammalian cells has nowadays become of extreme importance in the field of functional genomics and translational medicine. The advent of RNAi technology has brought to the scientific research and pharmaceutical communities the ability to regulate expression of any desired gene in a reproducible manner. Consequently, such technology may be utilised in the design of novel therapeutics for clinical conditions having dys-regulated gene expression. Since most RNAi-based therapies in the drug development pipeline of pharmaceutical companies utilise short interfering RNA (siRNA), this review will focus on the role of siRNA in drug development. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/927 |
Appears in Collections: | MMJ, Volume 21, Issue 3 MMJ, Volume 21, Issue 3 Scholarly Works - FacM&SPat |
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2009.Vol21.Issue3.A2.pdf | Unlocking the potential of RNA interference as a therapeutic tool | 327.07 kB | Adobe PDF | View/Open |
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