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https://www.um.edu.mt/library/oar/handle/123456789/103380| Title: | Protein C deficiency screening using a thrombin generation assay – an upgrade |
| Authors: | Gatt, Alexander van Veen, Joost J. Cooper, Peter Kitchen, Steve Makris, Michael |
| Keywords: | Protein C deficiency -- Pathophysiology Thrombin -- Physiological effect |
| Issue Date: | 2007 |
| Publisher: | Georg Thieme Verlag |
| Citation: | Gatt, A., van Veen, J. J., Cooper, P., Kitchen, S., & Makris, M. (2007). Protein C deficiency screening using a thrombin generation assay–an upgrade. Thrombosis and Haemostasis, 98(09), 691-692. |
| Abstract: | We read with interest the letter by Hézard et al. regarding a modified thrombin generation (TG) assay using Protac® as a screening tool for protein C (PC) deficiency. We have developed a similar modification in order to make the TG- assay more sensitive to changes in the protein C pathway. We tested 122 patients (32 controls, 38 heterozygous for factor V Leiden, 34 family members of patients with an inherited thrombophilia with normal thrombophilia screens, 8 with PC deficiency and 10 with protein S deficiency) enrolled in a previous thrombophilia study. Although our assay is similar to the assay described by Hézard et al., we feel that there are important differences that impact on the reproducibility and accuracy of this test. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/103380 |
| Appears in Collections: | Scholarly Works - FacM&SPat |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Protein C deficiency screening using a thrombin generation assay an upgrade 2007.pdf Restricted Access | 125.17 kB | Adobe PDF | View/Open Request a copy |
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