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Title: | Randomized clinical trial of the antiplatelet effects of aspirin–clopidogrel combination versus aspirin alone after lower limb angioplasty |
Authors: | Cassar, Kevin Ford, Isabel Greaves, Mike Bachoo, Paul Brittenden, Julie |
Keywords: | Clopidogrel Blood platelet disorders Aspirin Intermittent claudication -- Patients Blood platelets -- Activation Leg -- Blood-vessels -- Diseases Clinical trials |
Issue Date: | 2005 |
Publisher: | Wiley-Blackwell Publishing Ltd. |
Citation: | Cassar, K., Ford, I., Greaves, M., Bachoo, P., & Brittenden, J. (2005). Randomized clinical trial of the antiplatelet effects of aspirin–clopidogrel combination versus aspirin alone after lower limb angioplasty. Journal of British Surgery, 92(2), 159-165. |
Abstract: | There is a high risk of reocclusion after successful lower limb angioplasty. Platelets play a central role in this process. The aim of this study was to investigate the antiplatelet effect of a combination of aspirin and clopidogrel compared with aspirin alone in patients with claudication undergoing endovascular revascularization. Methods This was a double-blind randomized placebo-controlled trial. Some 132 patients were randomized to clopidogrel and aspirin or placebo and aspirin, with a loading dose 12 h before endovascular intervention. Flow cytometric measurements of platelet fibrinogen binding and P-selectin expression were taken as measures of platelet function at baseline, 12 h after the loading dose, and 1 h, 24 h and 30 days after intervention. Results Within 12 h of the loading dose, platelet activation in the clopidogrel group had decreased (P-selectin by 27·3 per cent, P = 0·017; fibrinogen binding by 34·7 per cent, P = 0·024; stimulated fibrinogen binding by 49·2 per cent, P < 0·001). No change was observed in the placebo group. Platelet function in the clopidogrel group was significantly suppressed compared with baseline at 1 h, 24 h and 30 days after endovascular intervention (stimulated fibrinogen binding by 53·9, 51·7 and 57·2 per cent respectively; all P < 0·001). Conclusion A combination of clopidogrel and aspirin inhibited platelet function more than aspirin alone in patients with claudication before and after angioplasty. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/103785 |
ISSN: | 13652168 |
Appears in Collections: | Scholarly Works - FacM&SSur |
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Randomized_clinical_trial_of_the_antiplatelet_effects_of_aspirin–clopidogrel_combination_versus_aspirin_alone_after_lower_limb_angioplasty(2005).pdf | 449.59 kB | Adobe PDF | View/Open |
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