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DC Field | Value | Language |
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dc.contributor.author | Grech, Godfrey | - |
dc.contributor.author | Saliba, Christian | - |
dc.contributor.author | Baldacchino, Shawn | - |
dc.contributor.author | Avellino, Roberto | - |
dc.contributor.author | Valk, P. J. M. | - |
dc.contributor.author | Delwel, R. | - |
dc.date.accessioned | 2022-12-02T14:40:54Z | - |
dc.date.available | 2022-12-02T14:40:54Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Grech, G., Saliba, C., Baldacchino, S., Avellino, R., Valk, P. J. M., & Delwel, R. (2012). Transcript variants and isoforms of the phosphatase subunit PPP2CA and its regulatory binding partners in haematological malignancies. Virchows Archiv, 461(Suppl. 1), S166-S166. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/104226 | - |
dc.description.abstract | Objective: The importance of feedback mechanisms involved in suppression of growth factor-induced signals is gaining importance both to understand molecular mechanisms of disease and also as potential therapeutic targets. Our previous studies show that erythroid differentiation can be blocked by constitutive expression of the pp2a inhibiting subunit, alpha4. The aim of this study was to identify variants and transcript isoforms of PPP2CA and the inhibiting subunits alpha4 and SET, using (1) cell lines derived from haematopoietic disease, and (2) Chronic Myeloid Leukemia (CML) and Acute Myeloid Leukemia (AML) patient material. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Springer | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Phosphoprotein phosphatases | en_GB |
dc.subject | Cancer -- Molecular aspects | en_GB |
dc.subject | Hematological oncology | en_GB |
dc.subject | Protein Isoforms | en_GB |
dc.title | Transcript variants and isoforms of the phosphatase subunit PPP2CA and its regulatory binding partners in haematological malignancies | en_GB |
dc.title.alternative | PS-10-019 Transcript variants and isoforms of the phosphatase subunit PPP2CA and its regulatory binding partners in haematological malignancies | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.publication.title | Virchows Archiv | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPat |
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Transcript variants and isoforms of the phosphatase subunit PPP2CA and its regulatory binding partners in haematological malignancies 2012.pdf Restricted Access | 47.18 kB | Adobe PDF | View/Open Request a copy |
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