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https://www.um.edu.mt/library/oar/handle/123456789/104226| Title: | Transcript variants and isoforms of the phosphatase subunit PPP2CA and its regulatory binding partners in haematological malignancies |
| Other Titles: | PS-10-019 Transcript variants and isoforms of the phosphatase subunit PPP2CA and its regulatory binding partners in haematological malignancies |
| Authors: | Grech, Godfrey Saliba, Christian Baldacchino, Shawn Avellino, Roberto Valk, P. J. M. Delwel, R. |
| Keywords: | Phosphoprotein phosphatases Cancer -- Molecular aspects Hematological oncology Protein Isoforms |
| Issue Date: | 2012 |
| Publisher: | Springer |
| Citation: | Grech, G., Saliba, C., Baldacchino, S., Avellino, R., Valk, P. J. M., & Delwel, R. (2012). Transcript variants and isoforms of the phosphatase subunit PPP2CA and its regulatory binding partners in haematological malignancies. Virchows Archiv, 461(Suppl. 1), S166-S166. |
| Abstract: | Objective: The importance of feedback mechanisms involved in suppression of growth factor-induced signals is gaining importance both to understand molecular mechanisms of disease and also as potential therapeutic targets. Our previous studies show that erythroid differentiation can be blocked by constitutive expression of the pp2a inhibiting subunit, alpha4. The aim of this study was to identify variants and transcript isoforms of PPP2CA and the inhibiting subunits alpha4 and SET, using (1) cell lines derived from haematopoietic disease, and (2) Chronic Myeloid Leukemia (CML) and Acute Myeloid Leukemia (AML) patient material. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/104226 |
| Appears in Collections: | Scholarly Works - FacM&SPat |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Transcript variants and isoforms of the phosphatase subunit PPP2CA and its regulatory binding partners in haematological malignancies 2012.pdf Restricted Access | 47.18 kB | Adobe PDF | View/Open Request a copy |
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