Intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profiling

Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/108748

Title:	Intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profiling
Other Titles:	Abstract 1915 : intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profiling
Authors:	Scerri, Jeanesse Ruoff, Felix Templin, Markus Grech, Godfrey Scerri, Christian
Keywords:	Breast -- Cancer -- Chemotherapy Monoclonal antibodies Trastuzumab HER-2 protein Cancer -- Gene therapy
Issue Date:	2020
Publisher:	American Association for Cancer Research
Citation:	Scerri, J., Ruoff, F., Templin, M., Grech, G., & Scerri, C. (2020). Intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profiling. Cancer Research, 80(16_Supplement), 1915-1915.
Abstract:	Introduction: The widespread clinical use of monoclonal antibodies such as trastuzumab in personalized medicine, targeting upstream proteins such as receptors with cascading effects on downstream signaling, elicits the importance of studying the phosphoproteome in the investigation of resistance to targeted therapy. This study sought to differentiate between the complex mechanisms of intrinsic and acquired trastuzumab resistance, by quantifying changes in expression and activity of proteins in key signal transduction pathways, in cellular models of resistance.
URI:	https://www.um.edu.mt/library/oar/handle/123456789/108748
Appears in Collections:	Scholarly Works - FacM&SPat

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