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Title: | Intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profiling |
Other Titles: | Abstract 1915 : intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profiling |
Authors: | Scerri, Jeanesse Ruoff, Felix Templin, Markus Grech, Godfrey Scerri, Christian |
Keywords: | Breast -- Cancer -- Chemotherapy Monoclonal antibodies Trastuzumab HER-2 protein Cancer -- Gene therapy |
Issue Date: | 2020 |
Publisher: | American Association for Cancer Research |
Citation: | Scerri, J., Ruoff, F., Templin, M., Grech, G., & Scerri, C. (2020). Intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest® phospho-protein profiling. Cancer Research, 80(16_Supplement), 1915-1915. |
Abstract: | Introduction: The widespread clinical use of monoclonal antibodies such as trastuzumab in personalized medicine, targeting upstream proteins such as receptors with cascading effects on downstream signaling, elicits the importance of studying the phosphoproteome in the investigation of resistance to targeted therapy. This study sought to differentiate between the complex mechanisms of intrinsic and acquired trastuzumab resistance, by quantifying changes in expression and activity of proteins in key signal transduction pathways, in cellular models of resistance. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/108748 |
Appears in Collections: | Scholarly Works - FacM&SPat |
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Intrinsic and acquired trastuzumab resistance pathways in breast cancer cell lines using DigiWest phospho protein profiling 2020.pdf Restricted Access | 147.05 kB | Adobe PDF | View/Open Request a copy |
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